Evaluation of clinical application value of combined blood culture of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 in bloodstream infections
Objective To explore the clinical application value of combined blood culture of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 for bloodstream infections.Methods A total of 58 patients with local non bloodstream infections and 58 patients with bloodstream infections were selected as a control group and an observation group,respectively.Blood specimens of the two groups of patients were collected for blood cultures,and after determining the positivity,the culture solution were extracted for Gram staining and bacterial identification;the levels of procalcitonin,hypersensitive C-reactive protein and interleukin-6 were detected.The procalcitonin,hypersensitive C-reactive protein,and interleukin-6 levels were compared between the two groups of patients,between patients with Gram-negative and Gram-positive bacterial infections in the observation group.Results In the observation group,the procalcitonin was(3.50±0.94)ng/ml,the hypersensitive C-reactive protein was(121.00±23.00)mg/L,and the interleukin-6 was(428.34±76.39)pg/ml,which were higher than(0.07±0.01)ng/ml,(57.00±11.00)mg/L,(0.58±0.02)pg/ml in the control group,and the difference was statistically significant(P＜0.05).In the observation group,procalcitonin of(5.93±0.18)ng/ml in patients with Gram-negative bacterial infection was higher than(1.06±0.01)ng/ml in patients with Gram-positive bacterial infection,and the difference was statistically significant(P＜0.05).Patients with Gram-negative bacterial infection had hypersensitive C-reactive protein of(118.00±23.00)mg/L and interleukin-6 of(423.39±44.53)pg/ml,which were slightly lower than(124.00±21.00)mg/L and(433.28±54.30)pg/ml in patients with Gram-positive bacterial infection,but the difference was not statistically significant(P＞0.05).Conclusion The concentrations of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 in patients with bloodstream infection are all in a high level,which can be used as an important basis for diagnosing bloodstream infection.Combined blood culture has high diagnostic accuracy,and can clarify the patient's condition in a timely manner to facilitate the formulation of the next treatment plan and promote the improvement of prognosis.
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