Effect of craniotomy hematoma removal combined with Angong Niuhuang pill in the treatment of severe cerebral hemorrhage and its influence on cognitive function
Objective To explore the effect of craniotomy hematoma removal combined with Angong Niuhuang pill in the treatment of severe cerebral hemorrhage and observe its influence on cognitive function of patients.Methods 63 patients with severe cerebral hemorrhage were selected and divided into a control group(30 cases)and an observation group(33 cases)by random table method.The control group was treated with craniotomy hematoma removal,and the observation group was treated with Angong Niuhuang pill.Both groups were compared in terms of clinical efficacy,cerebral hemodynamic parameters(cerebral critical force,mean blood flow velocity,mean blood flow),neuronal factors[neuron specific enolase(NSE),S100β],neural function[modified Rankin scale(mRS)score]and cognitive function[Montreal cognitive assessment scale(MoCA)score]before and after treatment.Results The total effective rate of treatment in the observation group was 93.94%,which was higher than 73.33% in the control group(P＜0.05).After treatment,the cerebrovascular critical force of(9.60±1.27)kPa in the observation group was lower than(10.38±1.52)kPa in the control group;the observation group had blood flow velocity of(97.42±1.39)cm/s and blood flow of(14.95±4.30)ml/s,which were higher than(86.54±1.60)cm/s and(12.07±4.23)ml/s in the control group(P＜0.05).After treatment,the observation group had serum NSE of(15.26±1.63)ng/ml and S100β of(0.96±0.27)μg/L,which were lower than(18.78±2.34)ng/ml and(1.18±0.31)μg/L in the control group(P＜0.05).After treatment,the mRS score of(2.17±0.15)points in the observation group was lower than(2.91±0.26)points in the control group(P＜0.05).After treatment,the MoCA score of(19.56±2.87)points in the observation group was higher than(16.71±3.15)points in the control group(P＜0.05).Conclusion Clinical application of craniotomy hematoma removal combined with Angong Niuhuang pill in the treatment of severe cerebral hemorrhage is feasible,which can improve clinical efficacy,improve cerebral hemodynamics,regulate neuronal factors,and gradually restore the neurological and cognitive functions of patients.
Craniotomy hematoma removalAngong Niuhuang pillSevere cerebral hemorrhageCognitive function
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