Study on the effect of amiodarone in emergency treatment of heart failure with rapid atrial fibrillation
Objective To analyze the effect of amiodarone in emergency treatment of heart failure with rapid atrial fibrillation.Methods 80 patients with heart failure accompanied by rapid atrial fibrillation were selected for study.The patients were randomly divided into an experimental group and a control group,each with 40 cases.The control group was given routine treatment,and the experimental group was given amiodarone emergency treatment.Both groups were compared in terms of therapeutic effect,heart rate,cardioversion at<3 h of medication and 3-8 h after medication,incidence of adverse reactions(nausea,vomiting,vertigo),blood pressure,cardiac function,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and D-dimer(D-D).Results The total effective rate of 97.5% in the experimental group was higher than 82.5% in the control group(P<0.05).The heart rates in the experimental group at 15 min,30 min,1 h,6 h,12 h and 24 h after medication were lower than those in the control group(P<0.05).The cardioversion success rate of 90.0% in the experimental group was significantly higher than 52.5% in the control group(P<0.05).The incidence of adverse reactions of 10.0% in the experimental group was lower than 27.5% in the control group(P<0.05).After treatment,the experimental group had systolic blood pressure of(117.25±5.62)mm Hg(1 mm Hg=0.133 kPa),diastolic blood pressure of(70.25±4.62)mm Hg),cardiac output of(5.58±0.32)L/min,left ventricular ejection fraction of(61.25±3.48)% and left ventricular end-diastolic diameter of(40.25±4.62)mm,which were better than(128.25±5.14)mm Hg,(79.14±4.38)mm Hg,(4.25±0.45)L/min,(55.58±4.33)% and(44.52±3.69)mm in the control group(P<0.05).The experimental group had LDL-C of(2.02±0.06)mmol/L,HDL-C of(1.89±0.26)mmol/L and D-D of(0.18±0.05)ng/L,which were lower than(2.81±0.14)mmol/L,(1.31±0.22)mmol/L and(0.42±0.06)ng/L in the control group(P<0.05).Conclusion Emergency treatment with amiodarone for heart failure accompanied by rapid atrial fibrillation has a higher level of physical recovery,better improvement in cardiac function indicators and heart rate,and is of great significance in promoting patient prognosis and ensuring patient safety.Amiodarone emergency treatment has a higher safety,so it can be widely used in clinical treatment.
Emergency treatment with amiodaroneHeart failureRapid atrial fibrillationTreatment effect