Clinical effect analysis of atorvastatin combined with trimetazidine in the treatment of coronary heart disease
Objective To analyze the efficacy of atorvastatin combined with trimetazidine in the treatment of patients with coronary heart disease.Methods 60 patients with coronary heart disease were divided into a conventional group and a study group by random sampling method,each with 30 cases.The conventional group was treated with trimetazidine,and the study group was treated with atorvastatin+trimetazidine.The therapeutic effect,blood lipid index,endothelial function index,cardiac function index and attack of angina pectoris were compared between the two groups.Results The total effective rate of the study group was 90.00%,which was higher than 66.67% of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the study group had total cholesterol of(3.73±0.05)mmol/L,triglyceride of(1.05±0.14)mmol/L and low density lipoprotein cholesterol of(1.16±0.20)mmol/L,which were lower than(5.18±0.66),(1.88±0.36)and(3.37±0.95)mmol/L in the conventional group;the high density lipoprotein cholesterol of(1.88±0.36)mmol/L in the study group was higher than(1.04±0.11)mmol/L in the conventional group;the difference was statistically significant(P<0.05).After treatment,the nitric oxide of(396.87±67.86)μg/L in the study group was higher than(310.13±50.88)μg/L in the conventional group;the study group had endothelin-1 of(50.05±2.02)μg/L and peripheral circulating endothelial microparticle of(854.67±261.37)×106/L,which were lower than(87.76±4.28)μg/L and(1073.18±212.54)×106/L in the conventional group;the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction of(52.28±2.84)% in the study group was higher than(40.80±2.56)% in the conventional group;the study group had left ventricular end-systolic diameter of(38.03±2.05)mm and left ventricular end-diastolic diameter of(50.05±2.42)mm,which were smaller than(58.78±3.36)and(66.68±4.18)mm in the conventional group;the difference was statistically significant(P<0.05).After treatment,the duration of angina pectoris of(3.84±0.74)min/time in the study group was shorter than(7.21±1.91)min/time in the conventional group,and the frequency of angina pectoris of(2.72±0.44)times/week was less than(4.73±0.74)times/week in the conventional group;the pain degree score of(2.34±0.24)points in the study group was lower than(4.17±0.51)points in the conventional group;the difference was statistically significant(P<0.05).Conclusion The combined treatment of atorvastatin and trimetazidine shows significant curative effect on patients with coronary heart disease,the cardiac function is significantly improved,the frequency of angina pectoris is significantly reduced,and the pain degree of patients is reduced.This method contains high clinical application value.