首页|无创通气联合牛肺表面活性剂治疗新生儿呼吸窘迫综合征的疗效及对患儿肺氧合功能、血气指标、肺循环功能的影响

无创通气联合牛肺表面活性剂治疗新生儿呼吸窘迫综合征的疗效及对患儿肺氧合功能、血气指标、肺循环功能的影响

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目的 探究无创通气联合牛肺表面活性剂治疗新生儿呼吸窘迫综合征(NRDS)的疗效及对患儿肺氧合功能、血气指标、肺循环功能的影响.方法 选取 80 例NRDS患儿为研究对象,按治疗方法不同分成对照组(采用无创通气治疗,n=40)和研究组(采用无创通气联合牛肺表面活性剂治疗,n=40).比较两组临床疗效、肺氧合功能[动脉血氧饱和度(SaO2)、氧合指数(PaO2/FiO2)]、血气指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]、肺循环功能[肺动脉压(PAP)、血管外肺水含量(EVLW)、肺血管阻力(PVR)].结果 治疗后,研究组的总有效率 95.00%高于对照组的 80.00%(P<0.05).治疗后,两组SaO2、PaO2/FiO2 均高于治疗前,且研究组SaO2(95.37±3.52)%、PaO2/FiO2(295.66±30.35)mm Hg(1 mm Hg=0.133 kPa)均高于对照组的(91.62±3.43)%、(263.89±28.74)mm Hg(P<0.05).治疗后,两组PaO2 高于治疗前、PaCO2 低于治疗前,且研究组PaO2(81.71±6.37)mm Hg高于对照组的(73.24±6.33)mm Hg、PaCO2(36.42±4.79)mm Hg低于对照组的(43.34±5.27)mm Hg(P<0.05).治疗后,两组PAP、EVLW、PVR均低于治疗前,且研究组PAP(22.47±1.51)mm Hg、EVLW(5.56±1.62)ml/kg、PVR(22.47±5.67)kPa·s/L均低于对照组的(25.33±2.24)mm Hg、(8.41±2.55)ml/kg、(29.31±6.25)kPa·s/L(P<0.05).结论 针对NRDS患儿,无创通气联合牛肺表面活性剂治疗具有显著疗效,能有效改善患儿的肺氧合功能、血气指标及肺循环功能.
Efficacy of noninvasive ventilation combined with bovine pulmonary surfactant on neonatal respiratory distress syndrome and its influence on pulmonary oxygenation,blood gas index and pulmonary circulatory function
Objective To explore the efficacy of noninvasive ventilation combined with bovine pulmonary surfactant on neonatal respiratory distress syndrome(NRDS)and its influence on pulmonary oxygenation,blood gas index and pulmonary circulatory function.Methods 80 children with NRDS were selected as research subjects and divided into a control group(noninvasive ventilation treatment,n=40)and a study group(noninvasive ventilation combined with bovine pulmonary surfactant treatment,n=40)according to different treatment methods.Comparison was made on clinical efficacy,pulmonary oxygenation function[arterial oxygen saturation(SaO2),oxygenation index(PaO2/FiO2)],blood gas index[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],pulmonary circulation function[pulmonary artery pressure(PAP),extravascular lung water(EVLW),pulmonary vascular resistance(PVR)between the two groups.Results After treatment,the total effective rate of 95.00% in the study group was higher than 80.00% in the control group(P<0.05).After treatment,SaO2,PaO2/FiO2 in both groups were higher than those before treatment;the study group had SaO2 of(95.37±3.52)% and PaO2/FiO2 of(295.66±30.35)mm Hg(1 mm Hg=0.133 kPa),which were higher than(91.62±3.43)% and(263.89±28.74)mm Hg in the control group(P<0.05).After treatment,PaO2 in both groups was higher than that before treatment,and PaCO2 was lower than that before treatment;PaO2 of(81.71±6.37)mm Hg in the study group was higher than(73.24±6.33)mm Hg in the control group,and PaCO2 of(36.42±4.79)mm Hg was lower than(43.34±5.27)mm Hg in the control group(P<0.05).After treatment,PAP,EVLW and PVR in both groups were lower than those before treatment;the study group had PAP of(22.47±1.51)mm Hg,EVLW of(5.56±1.62)ml/kg and PVR of(22.47±5.67)kPa·s/L,which were lower than(25.33±2.24)mm Hg,(8.41±2.55)ml/kg and(29.31±6.25)kPa·s/L in the control group(P<0.05).Conclusion For children with NRDS,non-invasive ventilation combined with bovine pulmonary surfactant has a significant effect,which can effectively improve the pulmonary oxygenation function,blood gas index and pulmonary circulation function of children.

Noninvasive ventilationBovine pulmonary surfactantNeonatal respiratory distress syndromePulmonary oxygenationBlood gas indexPulmonary circulatory function

宋晓正

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264200 青岛大学附属威海市立第二医院新生儿科

无创通气 牛肺表面活性剂 新生儿呼吸窘迫综合征 肺氧合功能 血气指标 肺循环功能

2024

中国现代药物应用
中国水利电力医学科学技术学会

中国现代药物应用

影响因子:0.862
ISSN:1673-9523
年,卷(期):2024.18(18)