Study on effect of aspirin and gamma globulin combined with glucocorticoids in the the treatment of pediatric Kawasaki's disease
Objective To analyze the value of aspirin and gamma globulin combined with glucocorticoids in the the treatment of pediatric Kawasaki's disease.Methods 160 children with Kawasaki's disease were divided into a reference group and a study group according to random numerical table,each with 80 cases.The reference group was treated with aspirin combined with gamma globulin,and the study group was treated with aspirin and gamma globulin combined with glucocorticoids.The therapeutic effect,elimination time of clinical symptoms and signs,related indicators(aspartate transaminase,alanine aminotrasferase,total bile acid,C-reactive protein,erythrocyte sedimentation rate).Results The total effective rate was 97.50% in the study group and 87.50% in the reference group.The total effective rate of the study group was higher compared with the reference group(χ2=5.7658,P=0.0163＜0.05).In the study group,the elimination time of mucosal congestion,rash,fever,cervical lymph node enlargement,conjunctival congestion,and limb hard swelling were(2.55±1.05),(3.89±1.56),(1.30±0.78),(2.39±1.05),(2.56±0.98),and(2.89±1.21)d,which were shorter than(4.33±1.98),(6.52±1.79),(3.91±1.23),(4.66±2.05),(3.98±1.21),and(5.61±1.26)d in the reference group(P＜0.05).After treatment,the levels of aspartate transaminase,alanine aminotrasferase,total bile acid,C-reactive protein and erythrocyte sedimentation rate in both groups were lower than those before treatment;in the study group,the aspartate transaminase was(37.56±3.98)U/L,the alanine aminotransferase was(42.05±2.15)U/L,the total bile acid was(7.80±1.36)μmol/L,the C-reactive protein was(10.28±2.15)mg/L and the erythrocyte sedimentation rate was(14.62±2.98)mm/h,which were lower than(48.63±6.56)U/L,(58.56±3.69)U/L,(11.00±2.12)μmol/L,(18.98±3.65)mg/L and(22.65±3.96)mm/h in the reference group(P＜0.05).Conclusion Aspirin combined with gamma globulin and glucocorticoids show significant effect on pediatric Kawasaki's disease,which can promote the regression of symptoms,improve the recovery effect of liver function,and has high application value.
Pediatric Kawasaki's diseaseAspirinGamma globulinCorticosteroidsSymptom elimination time
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