Effect of chemotherapy combined with Shenyi Jianzhong Decoction on immune indexes and quality of life of advanced gastric cancer patients
Objective To expolre the short-term efficacy of chemotherapy combined with Shenyi Jianzhong Decoction in the treatment of advanced gastric cancer patients,and observe its influence on the immune indexes and quality of life of patients.Methods 65 patients with advanced gastric cancer were divided into a control group(32 cases)and an observation group(33 cases)by odd-even number method.The control group was treated with chemotherapy,and the observation group was treated with Shenyi Jianzhong Decoction on the basis of the control group.The immune indexes,tumor markers,gastrointestinal function,quality of life score and short-term efficacy were compared between the two groups.Results After treatment,the immunoglobulin A,immunoglobulin G and immunoglobulin M in both groups were higher than those before treatment;the observation group had immunoglobulin A of(1.76±0.37)g/L,immunoglobulin G of(13.39±1.85)g/L and immunoglobulin M of(2.06±0.55)g/L,which were higher than(1.40±0.31),(1.40±0.31)and(1.70±0.62)g/L of the control group(P＜0.05).After treatment,the carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199)and carcinoembryonic antigen(CEA)in both groups were lower than those before treatment;the observation group had CA125 of(11.27±0.98)U/ml,CA199 of(16.93±1.06)U/ml and CEA of(1.70±0.35)ng/ml,which were lower than(21.82±1.03)U/ml,(20.69±1.45)U/ml and(4.32±0.26)ng/ml in the control group(P＜0.05).After treatment,the levels of pepsinogen Ⅰ(PG-Ⅰ)and gastrin(GAS)in both groups were higher than those before treatment;the observation group had higher PG-Ⅰ of(90.51±12.91)μg/L than(83.42±13.39)μg/L in the control group,and lower GAS of(15.60±2.56)ng/L than(17.75±2.92)ng/L in the control group(P＜0.05).After treatment,the quality of life score of the two groups was lower than that before treatment,and the observation group[(41.38±3.52)points]was lower than the control group[(56.41±3.73)points](P＜0.05).The total remission rate of 87.88% in the observation group was higher than 62.50% in the control group(P＜0.05).Conclusion Chemotherapy combined with Shenyi Jianzhong Decoction can improve the quality of life of patients with advanced gastric cancer,and has the role of improving immune indexes,regulating gastrointestinal function indicators and abnormal tumor markers.
ChemotherapyShenyi Jianzhong DecoctionAdvanced gastric cancerImmune indexesQuality of life
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