Observation on curative effect of Tongfu Xierejie Guanchang Mixture in treating adhesive intestinal obstruction in children
Objective To explore the effect of Tongfu Xierejie Guanchang Mixture in treating adhesive intestinal obstruction(AIO)in children.Methods A total of 82 children with AIO were selected and divided into a conventional group(treated with conventional treatment)and an enema group(treated with Tongfu Xierejie Guanchang Mixture on the basis of conventional treatment)by simple randomization method,with 41 cases in each group.Comparison was made on clinical efficacy,clinical symptom score,gastrointestinal function recovery,serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and the incidence of adverse events between the two groups.Results The total effective rate of treatment for children in the enema group was 92.68%,which was higher than 73.17% in the conventional group,and the difference was statistically significant(P＜0.05).At 3,5 and 7 d after treatment,the clinical symptom scores of children in both groups were lower than those before treatment;the clinical symptom scores were(17.28±4.85),(9.24±2.08)and(3.87±0.25)points in the enema group at 3,5,and 7 d after treatment,which were lower than(21.46±4.99),(15.23±3.31)and(7.95±1.14)points in the conventional group;the difference was statistically significant(P＜0.05).After treatment,the first exhaust time of the enema group was(2.29±0.54)d,the first defecation time was(3.35±0.83)d,the gastric tube removal time was(5.38±1.18)d and the length of hospital stay was(7.34±1.14)d,which were all shorter than(2.68±0.66),(4.28±1.08),(6.19±1.21),and(8.64±1.02)d in the conventional group,and the difference was statistically significant(P＜0.05).After treatment,the levels of CRP,IL-6 and TNF-α in both groups were lower than those before treatment;the enema group had CRP of(5.39±1.59)mg/L,IL-6 of(23.58±4.69)pg/ml and TNF-α of(18.62±4.24)ng/L,which were lower than(9.44±2.77)mg/L,(31.28±5.36)pg/ml and(31.26±5.86)ng/L in the conventional group;the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse events between the two groups(P＞0.05).Conclusion Tongfu Xierejie Guanchang Mixture is effective in the treatment of AIO in children,which can effectively relieve the clinical symptoms of children,shorten the recovery time,and has high safety.
Tongfu Xierejie Guanchang MixtureAdhesive intestinal obstruction in childrenGastrointestinal functionInflammatory factors
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