The effect analysis of tirofiban combined with interventional thrombectomy on neurological and coagulation function indicators of acute ischemic stroke patients
Objective To analyze the effect of tirofiban combined with interventional thrombectomy on neurological and coagulation function indicators of acute ischemic stroke(AIS)patients.Methods A total of 80 AIS patients were randomly divided into a control group and an observation group,with 40 patients in each group.The control group received interventional thrombectomy,while the observation group received treatment with tirofiban.Comparison was made on the clinical efficacy,neurological function[National Institutes of Health Stroke Scale(NIHSS)score,central nervous specific protein-β(S100β),brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)],coagulation function indicators[prothrombin time(PT),fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(APTT)],inflammatory cytokine[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]levels,quality of life,and occurrence of adverse events between two groups.Results The total effective rate of 92.50%in the observation group was higher than 75.00%in the control group(P<0.05).After treatment,NIHSS score and S100β in both groups were lower than those before treatment,and BDNF and NGF were higher than those before treatment;the observation group had NIHSS score of(6.59±0.97)points and S100β of(0.31±0.02)μg/L,which were lower than(9.41±1.25)points and(0.47±0.05)μg/L in the control group;the observation group had BDNF of(46.56±4.21)ng/ml and NGF of(12.41±2.57)pg/ml,which were higher than(36.75±3.41)ng/ml and(8.83±2.26)pg/ml in the control group(P<0.05).After treatment,PT,APTT and TT in both groups were longer than those before treatment,and FIB was lower than that before treatment;the observation group had PT of(12.83±2.35)s,APTT of(30.48±3.71)s and TT of(17.98±2.84)s,which were longer than(11.27±1.95),(26.84±3.05)and(15.39±2.18)s in the control group;FIB of(2.98±0.35)g/L in the observation group was lower than(3.53±0.61)g/L in the control group(P<0.05).After treatment,IL-6,CRP and TNF-α decreased in both groups compared with those before treatment;the observation group had IL-6 of(67.54±8.97)pg/ml,CRP of(4.69±1.05)mg/L and TNF-α of(5.35±1.16)ng/ml,which were lower than(86.71±11.35)pg/ml,(7.53±1.67)mg/L and(8.71±1.53)ng/ml in the control group(P<0.05).After treatment,the scores of psychological function,physical function,social function and material life status of the two groups were higher than those before treatment,and the scores of psychological function,physical function,social function and material life status of the observation group were higher than those of the control group(P<0.05).There was no difference in the incidence of adverse events between the two groups(P>0.05).Conclusion Tirofiban combined with interventional thrombectomy can protect the neurological function,improve coagulation function,control inflammatory response,improve quality of life in AIS patients,and have no serious adverse events.It can be widely applied in clinical practice.
Acute ischemic strokeTirofibanInterventional thrombectomyNeurological functionBrain derived neurotrophic factorThrombin time
万方数据
维普
