Analysis of the effect of sacubitril valsartan sodium tablets on patients with ischemic cardiomyopathy and heart failure
Objective To analyze the effect of sacubitril valsartan sodium tablets on patients with ischemic cardiomyopathy and heart failure.Methods A total of 120 patients with ischemic cardiomyopathy and heart failure were selected and divided into an observation group(n=60,treated with conventional drugs combined with sacubitril valsartan sodium tablets)and a control group(n=60,treated with conventional drugs)by random number table method.Both groups were compared in terms of clinical efficacy,cardiac function[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDd)],serum N-terminal pro-brain natriuretic peptide(NT-proBNP)level,nutritional status[albumin(ALB),prealbumin(PA)],and the occurrence of adverse reactions.Results The total effective rate of 93.33%in the observation group was significantly higher than 80.00%in the control group(P<0.05).After treatment,the levels of LVEF,LVEDd and NT-proBNP were improved in both groups;the levels of LVEF,LVEDd and NT-proBNP in the observation group were(52.96±4.18)%,(51.20±4.63)mm and(1045.33±218.91)pg/ml,which were better than(48.50±4.06)%,(55.82±4.16)mm and(2561.27±308.96)pg/ml in the control group(P<0.05).After treatment,the levels of ALB and PA were increased in both groups;the observation group had ALB of(38.11±2.04)g/L and PA of(190.52±11.17)mg/L,which were higher than(36.76±2.30)g/L and(185.30±12.59)mg/L in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the clinical treatment of patients with ischemic cardiomyopathy and heart failure,the effect of sacubitril valsartan sodium tablets is more ideal,which can effectively improve the cardiac function and nutritional status of patients,and promote the improvement of prognosis.
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