Clinical test value and positive rate of urinary protein combined with urinary microalbumin in patients with diabetes nephropathy
Objective To analyze the clinical test value and positive rate of urinary protein combined with urinary microalbumin in patients with diabetes nephropathy.Methods 60 patients with diabetes nephropathy were selected as the experimental group,and 60 patients with simple diabetes admitted at the same time were selected as the control group.Both groups were tested for urinary protein and urinary microalbumin.The expression level and positive rate of urinary protein and urinary microalbumin were compared in the two groups.The clinical diagnosis results were taken as the gold standard to compare the diagnostic sensitivity,specificity,accuracy,positive predictive value,and negative predictive value for diabetic nephropathy by single urinary protein test,single urinary microalbumin test,and the combination of the two tests were compared.Results In the experimental group,the urinary protein level and positive rate were(160.25±20.25)mg/L and 58.33%,and the urinary microalbumin level and positive rate were(35.92±9.26)mg/L and 63.33%,which were higher than(131.25±17.33)mg/L,33.33%and(23.54±7.25)mg/L,30.00%in the control group(P<0.05).The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the single urinary protein test were 58.33%,66.67%,62.50%,63.64%,and 61.54%,respectively;the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the single urinary microalbumin test were 63.33%,70.00%,66.67%,67.86%,and 65.63%,respectively;the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the two combined tests were 93.33%,86.67%,90.00%,87.50%,and 92.86%,respectively.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the combined tests of urinary protein and microalbumin were higher than those of the single urinary protein test and the single urinary microalbumin test(P<0.05).There was no significant difference in the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value between the single urinary protein test and the single urinary microalbumin test(P>0.05).Conclusion There is an abnormal increase of urinary protein and microalbumin in patients with diabetes nephropathy.Therefore,the combination of urinary protein and microalbumin in the diagnosis of diabetes nephropathy can improve the sensitivity,specificity and accuracy of diagnosis,and has a very high application value.
万方数据
维普
