Effect analysis of edaravone and nimodipine with minimally invasive intracranial hematoma removal for the treatment of hypertensive cerebral hemorrhage
Objective To explore the clinical effect of edaravone and nimodipine with minimally invasive intracranial hematoma removal for the treatment of hypertensive cerebral hemorrhage.Methods 100 patients with hypertensive cerebral hemorrhage were randomly divided into an observation group and a control group,with 50 patients in single group.The control group underwent minimally invasive intracranial hematoma removal,and the observation group was treated with edaravone injection and nimodipine injection based on the control group.The serum inflammatory factors,blood coagulation indexes,hematoma volume before and after treatment,and prognosis were compared between the two groups.Results After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment;the observation group had hs-CRP of(13.93±3.25)mg/L,IL-6 of(34.96±1.48)pg/ml,and TNF-α of(9.63±0.86)pg/ml,which were lower than(19.78±4.17)mg/L,(47.64±1.59)pg/ml,and(13.52±3.19)pg/ml in the control group;there were significant differences(P<0.05).After treatment,the D-dimer(D-D),prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups were lower than those before treatment;D-D of(0.82±0.21)mg/L in the observation group was significantly lower than(1.39±0.39)mg/L in the control group;the observation group had PT of(12.93±0.98)s and APPT of(29.63±6.16)s,which shorter than(14.25±0.96)and(32.52±5.24)s in the control group;there were significant differences(P<0.05).After treatment,the hematoma volume of(3.64±0.31)ml in the observation group was smaller than(3.86±0.20)ml in the control group(P<0.05).The rate of excellent prognosis of 90.0%in the observation group was higher than 52.0%in the control group,and there were significant differences(P<0.05).Conclusion The combined application of edaravone and nimodipine during minimally invasive intracranial hematoma removal in patients with hypertensive cerebral hemorrhage can improve the patients'symptoms and reduce the hematoma volume,which is worthy of clinical reference.
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