Study on effects of different doses of mifepristone combined with laparoscopic surgery on hormone levels of patients with uterine fibroids
Objective To explore the effects of different doses of mifepristone combined with laparoscopic surgery on hormone levels of patients with uterine fibroids.Methods A total of 100 patients with uterine fibroids were selected and divided into a control group(50 cases)and an experimental group(50 cases)according to the lottery method.Laparoscopic surgery was performed in both groups.On this basis,the control group was treated with 25 mg mifepristone,and the experimental group was treated with 12.5 mg mifepristone.Comparison was made on clinical efficacy,postoperative recovery status(vaginal bleeding time,menstrual recovery time and uterine volume),sex hormones[serum progesterone(P),follicle stimulating hormone(FSH),estradiol(E2)],and pain degree between the two groups.Results The total effective rate of 96.00%in the experimental group was higher than 80.00%in the control group(P<0.05).In the experimental group,the postoperative vaginal bleeding time was(13.05±1.45)d and the menstrual recovery time was(33.34±4.05)d,which were shorter than(17.45±2.25)and(49.34±2.38)d in the control group(P<0.05).After treatment,the uterine volume in both groups was smaller than that before treatment,and the uterine volume of(107.89±8.98)cm3 in the experimental group was smaller than(124.45±12.47)cm3 in the control group(P<0.05).After treatment,the serum progesterone,FSH,E2 levels in both groups were lower than those before treatment;the experimental group had serum progesterone of(8.45±1.21)nmol/L,FSH of(14.32±2.47)U/L,and E2 of(130.89±23.32)pmol/L,which were lower than(11.62±1.29)nmol/L,(18.65±2.56)U/L,and(175.46±42.38)pmol/L in the control group(P<0.05).The percentage of grade Ⅰ pain in the experimental group was 74.00%,which was higher than 40.00%in the control group;the percentage of grade Ⅱ and Ⅲ pain in the experimental group were 20.00%and 6.00%,which were lower than 40.00%and 20.00%in the control group(P<0.05).Conclusion Compared with 25 mg mifepristone,12.5 mg mifepristone combined with laparoscopic surgery for the treatment of uterine fibroids can improve the clinical efficacy,reduce pain degree,improve sex hormone levels,promote rapid postoperative recovery of patients.
万方数据
维普
