Clinical efficacy of topical Nocardia rubra cell-wall skeleton in the treatment of persistent high-risk HPV infection of the cervix
Objective To explore the clinical effect of topical Nocardia rubra cell-wall skeleton(Nr-CWS)in the treatment of persistent high-risk human papillomavirus(HPV)infection of the cervix.Methods 100 patients with persistent high-risk HPV infection were randomly divided into a control group(50 cases)and a study group(50 cases).The control group was treated with interferon,and the study group was treated with Nr-CWS.Patients in both groups were compared in terms of HPV treatment effect and peripheral blood lymphocyte subsets(CD4+,CD8+,CD4+/CD8+)levels,levels of immune factors[interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)]in vaginal lavage fluid,and the occurrence of adverse reactions.Results The total effective rate of 96%in the study group was higher than 60%in the control group(P<0.05).After treatment,the peripheral blood CD4+and CD4+/CD8+in both groups were higher than those before treatment in this group;the study group had CD4+of(40.04±2.15)%and CD4+/CD8+of(1.30±0.16),which were higher than(36.46±3.61)%and(1.18±0.16)in the control group(P<0.05).Before and after treatment,there was no significant difference in CD8+between and within the two groups(P>0.05).After treatment,the levels of IL-2,IFN-γ and TNF-α in both groups were higher than those before treatment,while the level of IL-4 was lower than that before treatment;the study group had IL-2 of(97.24±4.13)ng/L,TNF-α of(36.68±3.14)ng/L and IFN-γ of(32.35±2.14)ng/L,which were higher than(92.15±5.04),(33.23±2.21)and(28.78±2.11)ng/L in the control group;IL-4 of(12.79±1.88)ng/L in the study group was lower than(14.52±2.13)ng/L in the control group(P<0.05).Before and after treatment,there was no significant difference in IL-6 and IL-10 between and within the two groups(P>0.05).No serious adverse reactions or discomfort occurred during treatment in both groups.Conclusion The use of Nr-CWS has a positive effect on improving the negative-conversion rate and cure rate of patients with persistent high-risk HPV infection of the cervix,and it is safe and can improve the quality of life,which is worth promoting.
Human papillomavirusCervical cancerTopical Nocardia rubra cell-wall skeletonImmune cellsImmune factors
万方数据
维普
