Analysis of clinical effect of empagliflozin combined with berberine in the treatment of fragile type 2 diabetes mellitus
Objective To analyze the clinical effect of empagliflozin combined with berberine in the treatment of fragile type 2 diabetes mellitus.Methods 98 patients with fragile type 2 diabetes mellitus were selected as research subjects,and were divided into an observation group and a control group according to random number table,with 49 cases in each group.Both groups were treated with insulin aspart.On this basis,the control group was treated with empagliflozin,and the observation group was treated with berberine on the basis of the control group.Blood glucose level,blood glucose fluctuation,blood lipid level,renal function level,oxidation products and antioxidant indexes and drug related adverse reactions were compared between the two groups.Results After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in the observation group were(6.89±0.64)mmol/L,(8.62±1.04)mmol/L and(6.42±0.58)%,which were lower than(7.58±0.52)mmol/L,(9.35±1.24)mmol/L and(7.58±0.47)%in the control group,and the difference was statistically significant(P<0.05).After treatment,the triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in the observation group were(0.80±0.23),(4.32±0.26)and(2.42±0.25)mmol/L,which were lower than(0.90±0.24),(5.05±0.35)and(2.89±0.42)mmol/L in the control group,and the difference was statistically significant(P<0.05).After treatment,the eostprandial glucose excursion(PPGE)and the means of daily differences(MODD)in the observation group were(0.60±0.24)and(1.42±0.35)mmol/L,which were lower than(2.15±0.65)and(2.12±0.46)mmol/L in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood urea nitrogen,serum creatinine and serum cystatin C in the observation group were(4.30±1.06)mmol/L,(81.24±12.06)μmol/L and(4.65±1.05)mg/L,which were lower than(6.24±1.08)mmol/L,(94.25±10.65)μmol/L,(6.35±0.24)mg/L in the control group;the endogenous creatinine clearance rate of(115.15±15.36)ml/(min·1.73 m2)in the observation group was higher than(105.25±14.24)ml/(min·1.73 m2)in the control group;the difference was statistically significant(P<0.05).After treatment,the superoxide dismutase(SOD)and catalase(CAT)in the observation group were(96.24±5.39)U/L and(41.36±3.58)U/ml,which were higher than(88.52±6.37)U/L and(37.25±3.46)U/ml in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the two groups(P>0.05).Conclusion Compared with gliflozin alone,combined with berberine can enhance the efficacy of fragile 2 diabetes,and have good safety.
EmpagliflozinBerberineFragile type 2 diabetes mellitus
万方数据
维普
