Effect of atropine combined with pralidoxime iodide in the treatment of patients with acute organophosphate pesticide poisoning and its influence on cholinesterase
Objective To explore the clinical effect of atropine combined with pralidoxime iodide in the treatment of patients with acute organophosphate pesticide poisoning(AOPP)and its influence on cholinesterase(ChE).Methods 76 patients with AOPP were grouped according to the drugs used for rescue treatment.Among them,38 patients treated with pralidoxime iodide were assigned to the control group;38 patients treated with atropine+pralidoxime iodide were assigned to the observation group.Comparison was made on coma time,mechanical ventilation time,and hospital stay,occurrence of complications,mortality,and ChE,creatine kinase(CK),and indicators of oxidative stress[malondialdehyde(MDA),and superoxide dismutase(SOD)]before and after treatment between the two groups.Results The observation group had coma time mechanical ventilation time and hospital stay was shorter than the control group(P<0.05).After treatment,the observation group had higher ChE than in the control group,and lower CK than the control group(P<0.05).The complication rate of 10.53%in the observation group was lower than 31.58%in the control group(P<0.05).After treatment,the observation group had lower MDA than the control group,and higher SOD than the control group(P<0.05).The mortality rate of 7.89%in the observation group was lower than 26.32%in the control group(P<0.05).Conclusion The combination of atropine and pralidoxime iodide has a more ideal therapeutic effect on AOPP patients,which can shorten the treatment time of patients,promote early improvement of ChE and CK levels,help reduce the incidence of complications,improve the oxidative stress level of patients,and lower the mortality rate.
万方数据
维普
