Effect of different fractionated radiotherapy modes on immune function of early breast cancer patients after breast conserving surgery
Objective To explore the effect of different fractionated radiotherapy modes on immune function of early breast cancer patients after breast conserving surgery. Methods A total of 110 cases of early breast cancer patients after breast conserving surgery were divided into an observation group and a control group according to random numerical table,with 55 patients in each group. Patients in the control group received the conventional fractionation radiotherapy,while patients in the observation group received the short-range and large-division radiotherapy. Both groups of patients were compared in terms of the organ-at-risk (OAR) dose,immune function (ratio of lymphocytes to monocytes) before and after treatment,and the incidence of adverse reactions to acute radiotherapy. Results In the observation group,the percent volume receiving at least 5 Gy (V5),percent volume receiving at least 10 Gy (V10),percent volume receiving at least 20 Gy (V20),average dose of the affected lung,and V5,V10,average dose of the healthy lung were (54.25±10.54)％,(28.04±9.65)％,(15.04±4.65)％,(1008.65±165.57) cGy and (3.88±1.02)％,(0.15±0.02)％,(196.35±31.49) cGy,which were lower than (70.68±12.32)％,(35.68±9.61)％,(17.51±3.58)％,(1305.47±188.34) cGy and (7.65±2.02)％,(0.99±0.14)％,(239.65±85.47) cGy in the control group;the difference was statistically significant (P<0.05). Before treatment,the ratio of lymphocyte to monocyte was (3.11±1.02) in the observation group and (3.36±1.20) in the control group;after treatment,the ratio of lymphocytes to monocytes was (1.92±0.34) in the observation group and (1.90±0.28) in the control group. Before treatment,there was no significant difference in ratio of lymphocyte to monocyte between the two groups (P>0.05). After treatment,the ratio of lymphocytes to monocytes in both groups was lower than that before treatment,and the difference was statistically significant (P<0.05). After treatment,there was no significant difference in ratio of lymphocyte to monocyte between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions to acute radiotherapy between the two groups (P>0.05). Conclusion Short-range and large-division radiotherapy can effectively reduce the dose levels received by some organs at risk,but also does not increase the risk of immunosuppression and adverse reactions after radiotherapy,which has a high safety and is worthy of promotion and application.
RadiotherapyBreast cancerEarly stageBreast conserving surgeryImmune function
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