The value of combined detection of serum D-dimer and FIB in early prediction of pregnancy-induced hypertension syndrome
Objective To investigate the value of combined detection of serum D-dimer (D-D) and fibrinogen (FIB) in early prediction of pregnancy-induced hypertension syndrome. Methods 100 cases of pregnant women with pregnancy-induced hypertension syndrome were selected as the observation group,including 64 cases of gestational hypertension (gestational hypertension group),22 cases of mild preeclampsia (mild preeclampsia group),and 14 cases of severe preeclampsia (severe preeclampsia group);and another 100 cases of healthy pregnant women with prenatal examination were selected as the control group. The coagulation-related indexes[FIB,thrombin time (TT),antithrombin Ⅲ (AT-Ⅲ),prothrombin time (PT),prothrombin time-international normalized ratio (PT-INR),activated partial thromboplastin time (ATPP)],D-D,fibrinolysis-related indexes[tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)]were tested and compared among the four groups. Results Comparison of FIB,AT-Ⅲ,PT,PT-INR and APTT among the four groups showed statistically significant differences (P<0.05). AT-Ⅲ,PT,PT-INR and APTT of gestational hypertension group,mild preeclampsia group and severe preeclampsia group were lower than those of the control group,and FIB was higher than that of the control group. The difference was statistically significant (P<0.05). In gestational hypertension group,D-D,tPA and PAI-1 levels were (289.59±25.26) μg/L,(8.15±0.74) U/ml and (37.85±5.06) ng/ml;in mild preeclampsia group,those were (357.15±26.69) μg/L,(8.69±0.56) U/ml and (38.48±5.53) ng/ml;in severe preeclampsia group,those were (428.48±27.26) μg/L,(9.08±0.32) U/ml and (51.48±6.26) ng/ml;in control group,those were (244.26±22.26) μg/L,(7.32±0.74) U/ml and (14.06±4.26) ng/ml. The levels of D-D,tPA and PAI-1 in gestational hypertension group,mild preeclampsia group and severe preeclampsia group were higher than those in the control group,and the differences were statistically significant (P<0.05). Conclusion Monitoring the levels of serum D-D,FIB and other related indexes of pregnant women with pregnancy-induced hypertension can find the abnormal coagulation and fibrinolysis function in time,and the more serious the condition is,the more obvious the changes of the above indexes are,which provides a reasonable basis for the prediction and treatment of clinical pregnancy-induced hypertension syndrome,and is worthy of application.
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