Effects of Bifico combined with mesalazine and Kangfuxin Solution on inflammatory factors and adverse reactions in patients with ulcerative colitis
Objective To explore the effects of live combined bifidobacterium,lactobacillus and enterococcus capsules (trade name:Bifico) combined with mesalazine and Kangfuxin Solution on inflammatory factors and adverse reactions in patients with ulcerative colitis. Methods 76 patients with ulcerative colitis were divided into a control group and an observation group according to the order of admission,with 38 cases in each group. The control group was treated with mesalazine combined with Kangfuxin Solution,and the observation group was treated with Bifico on the basis of the control group. Both groups were compared in terms of clinical efficacy,clinical symptoms (stool frequency,blood in stool,diarrhea,abdominal pain) score,levels of inflammatory factors[interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α),hypersensitive C-reactive protein (hs-CRP)]and occurrence of adverse reactions. Results The total effective rate of the observation group was 92.11％,which was higher than 73.68％ of the control group,and the difference was significant (P<0.05). After treatment,in the observation group,the stool frequency score was (0.75±0.23) points,the blood in stool score was (0.58±0.17) points,the diarrhea score was (0.53±0.16) points and the abdominal pain score was (0.59±0.15) points,which were all lower than (1.21±0.38),(0.84±0.21),(0.82±0.21) and (0.86±0.19) points in the control group,and the difference was significant (P<0.05). After treatment,the observation group had IL-8 of (140.64±32.83) μg/L,hs-CRP of (3.06±0.86) mg/L,and TNF-α of (37.17±9.22) ng/L,which were lower than (172.14±39.14) μg/L,(4.45±0.94) mg/L,and (48.55±9.53) ng/L in the control group,and the difference was significant (P<0.05). The incidence of adverse reactions of 5.26％ in the observation group was significantly lower than 21.05％ in the control group,and the difference was significant (P<0.05). Conclusion Bifico combined with mesalazine and Kangfuxin solution has a definite effect in the treatment of ulcerative colitis,and the clinical symptoms and the levels of inflammatory factors can be effectively improved,and the safety is high.
Live combined bifidobacterium,lactobacillus and enterococcus capsulesMesalazineKangfuxin SolutionUlcerative colitis
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