Comparison of clinical efficacy of single-port thoracoscopic surgery and two-port thoracoscopic surgery in the treatment of non-small cell lung cancer
Objective To compare the clinical effect of single-port thoracoscopic surgery and two-port thoracoscopic surgery in the treatment of non-small cell lung cancer.Methods A total of 200 patients with non-small cell lung cancer were divided into group A and group B according to random number table method,with 100 patients in each group.Patients in group A underwent two-port thoracoscopic surgery,and patients in group B underwent single-port thoracoscopic surgery.The perioperative related indicators,serum inflammatory factors,serum pain stress indicators and the occurrence of complications were compared between the two groups.Results In group B,the operation time was (156.13±32.96) d and the off-bed ambulation time was (5.71±0.52) d,which were shorter than (195.15±41.37) and (7.12±1.63) d in group A;the intraoperative blood loss of (90.21±21.19) ml was less than (115.15±26.01) ml in group A;the difference was significant (P<0.05).Compared with before surgery,the serum levels of interleukin-1 (IL-1),procalcitonin (PCT) and C-reactive protein (CRP) were increased in both groups after surgery;group B had CRP of (12.05±2.26) mg/L,PCT of (0.62±0.17) ng/ml and IL-1 of (10.95±2.96) ng/L,which were lower than (20.10±3.17) mg/L,(1.05±0.32) ng/ml and (23.13±4.75) ng/L in group A;the difference was significant (P<0.05).Compared with before surgery,the substance P (SP),prostaglandin E2 (PGE2),norepinephrine (NE) and cortisol (Cor) in both groups were increased after surgery;group B had SP of (8.12±1.13) μg/ml,PGE2 of (157.38±19.49) ng/L,NE of (155.11±23.62) ng/L and Cor of (136.75±16.19) ng/ml,which were lower than (17.03±2.53) μg/ml,(265.16±32.11) ng/L,(274.15±45.38) ng/L and (224.15±27.22) ng/ml in group A;the difference was significant (P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05).Conclusion In the treatment of patients with non-small cell lung cancer,single-port thoracoscopic surgery can shorten the operation time and the off-bed ambulation time,reduce the intraoperative blood loss,lower postoperative inflammation and pain stress level,and does not increase the risk of complications.
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