Objective To explore the effect of different mask ventilation modes on hemodynamics and gastric intake in children with tonsil adenoidectomy under general anesthesia.Methods A total of 100 cases who underwent tonsil adenoidectomy under general anesthesia were selected and grouped into group A (33 cases),group B (33 cases) and group C (34 cases) on the principle of randomized numerical table method.Group A was given manual controlled ventilation,group B was given pressure controlled ventilation (PCV) and group C was given pressure-controlled ventilation,volume-guaranteed (PCV-VG).Comparison was made on hemodynamic indexes[mean arterial pressure (MAP),heart rate (HR),oxygen saturation (SpO2)],gastric intake and the incidence of postoperative complications in the three groups at different time intervals[immediate disappearance of spontaneous respiration (T0),60 s of mask ventilation (T1),120 s of mask ventilation (T2),180 s of mask ventilation (T3)].Results Comparison of MAP and HR levels of the three groups at T0-T3,the differences were not statistically significant (P>0.05).At T0,SpO2 levels of the three groups of children were comparable,and the difference was not statistically significant (P>0.05).In group A,SpO2 at T1-T3 were (96.95±1.24)%,(96.63±1.19)% and (96.57±1.09)%,SpO2 at T1-T3 in group B were (97.27±1.21)%,(97.08±1.17)%,(96.91±1.11)%,SpO2 at T1-T3 in group C were (98.14±1.17)%,(97.86±1.20)%,(97.78±1.15)%,respectively.The difference in SpO2 levels among the three groups at T1-T3 was statistically significant (P<0.05),and SpO2 levels in group C were slightly higher than those in group A and group B.The incidence rates of gastric intake in group A,group B,and group C were 30.30%,9.09%,and 5.88%,respectively.The incidence of gastric intake in group B and group C was lower than that in group A,and the difference was statistically significant (P<0.05),and the difference in the incidence of gastric intake between group B and group C was not statistically significant when compared (P>0.05).The incidence of postoperative related complications was comparable in the three groups,and there was no statistically significant difference in pairwise comparisons of the three groups (P>0.05).Conclusion In tonsillar adenoidectomy under general anesthesia,PCV and PCV-VG ventilation modes are equally effective in maintaining lower peak airway pressure and less gastric intake.However,PCV-VG can better maintain tidal volume and lung compliance in children,and is more ideal for maintaining hemodynamic stability.