Study on the differential diagnostic value of serum Tg-Ab,TSH and TPO-Ab detection for benign and malignant thyroid nodules
Objective To analyze the differential diagnostic value of serum thyroglobulin antibody (Tg-Ab),thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPO-Ab) detection for benign and malignant thyroid nodules.Methods 67 patients with thyroid nodules were selected as the subjects.All cases were divided into 46 cases of benign group and 21 cases of malignant group by pathological results.Serum levels of Tg-Ab,TSH and TPO-Ab were detected and compared between the two groups.The receiver operating characteristic (ROC) curve was drawn,and the diagnostic value of three indicators for benign and malignant thyroid nodules was analyzed.Results The Tg-Ab of the malignant group was (129.81±9.63) IU/ml,TSH was (5.89±1.41) mIU/L and TPO-Ab was (37.46±3.58) IU/ml,which were higher than (65.40±5.37) IU/ml,(1.71±0.53) mIU/L and (21.57±2.39) IU/ml in the benign group (P<0.05).The ROC results showed that the area under the curve (AUC) of Tg-Ab,TSH,and TPO-Ab in combination for benign and malignant thyroid nodules was 0.913[95％CI=(0.840,0.985)],which was greater than 0.798[95％CI=(0.693,0.902)]by Tg-Ab alone,0.806[95％CI=(0.701,0.910)]by TSH alone,and 0.874[95％CI=(0.793,0.955)]by TPO-Ab alone.Conclusion The combined detection of Tg-Ab,TSH and TPO-Ab can effectively differentiate the benign and malignant thyroid nodules,which has certain diagnostic efficacy and is worthy of clinical application.
万方数据
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