Prediction of risk of 28-d mortality in patients with sepsis and septic shock by NGAL,NT-proBNP and LAC
Objective To explore the predictive value of risk of 28-d mortality in patients with sepsis and septic shock by serum neutrophil gelatinase associated lipocalin (NGAL),N-terminal pro-B-type natriuretic peptide (NT-proBNP) and lactic acid (LAC).Methods 62 patients with sepsis and septic shock were selected as the study subjects,and were divided into a study group (surviving patients) and a control group (dead patients) based on the survival of the patients after 28 d of treatment,with 31 patients in each group.The Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score,NGAL,NT-proBNP,and LAC levels were detected and compared between the two groups.Results The study group had SOFA score of (4.21±3.21) points and APACHE Ⅱ score of (13.42±3.69) points on day 28,which were lower than (7.83±3.29) and (22.19±5.02) points in the control group,and the differences were statistically significant (P<0.05).The study group had NGAL of (292.36±33.42) μg/L,NT-proBNP of (643.62±37.52) pg/ml,and LAC of (4.55±1.43) mmol/L,which were lower than (526.13±45.21) μg/L,(1321.69±59.32) pg/ml,and (6.79±1.32) mmol/L in the control group,and the differences were statistically significant (P<0.05).Conclusion NGAL,NT-proBNP and LAC have significant value in predicting the risk of 28-d mortality in patients with sepsis and septic shock.The higher the level of the three indicators,the higher the probability of patients with organ failure and nervous system abnormalities,which is worthy of clinical promotion and use.
SepsisSeptic shockNeutrophil gelatinase associated lipocalinN-terminal pro-B-type natriuretic peptideLactic acidRisk of death
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