Effect of Guhong injection combined with idibenone in the treatment of vascular dementia after cerebral infarction and its influence on cognitive function and hemorheology
Objective To explore the effect of Guhong injection combined with idibenone in the treatment of vascular dementia (VaD) after cerebral infarction and its influence on cognitive function and hemorheology.Methods 78 patients with VaD after cerebral infarction were divided into an observation group (39 cases) and a control group (39 cases) by random numerical table method.The control group was treated with idebenone,and the observation group was treated with Guhong injection combined with idebenone.The two groups were compared in terms of clinical efficacy,cognitive function[Montreal Cognitive Assessment (MoCA),Mini-Mental State Examination (MMSE) scores],hemorheology (plasma viscosity,whole-blood high-shear viscosity,whole-blood low-shear viscosity,fibrinogen),blood flow velocity of cerebral arteries[anterior cerebral arteries (ACA),middle cerebral arteries (MCA),posterior cerebral arteries (PCA)],and the incidence of adverse reactions.Results The total effective rate of 97.44％ in the observation group was significantly higher than 84.62％ in the control group (P<0.05).After treatment,MoCA and MMSE scores in both groups were significantly higher than those before treatment;MoCA score of (25.67±1.08) points and MMSE score of (25.98±1.65) points in the observation group were significantly higher than (21.69±1.39) and (22.39±1.94) points in the control group (P<0.05).After treatment,the plasma viscosity,whole-blood high-shear viscosity,whole-blood low-shear viscosity and fibrinogen in both groups were significantly lower than those before treatment;in the observation group,the plasma viscosity was (1.53±0.37) mPa·s,the whole-blood high-shear viscosity was (4.98±0.64) mPa·s,the whole-blood low-shear viscosity was (6.98±1.26) mPa·s,and the fibrinogen was (2.18±0.49) g/L,which were significantly lower than (2.16±0.42) mPa·s,(7.26±0.75) mPa·s,(8.26±1.38) mPa·s,and (3.08±0.73) g/L in the control group (P<0.05).After treatment,the blood flow velocity of ACA,MCA and PCA in both groups was significantly higher than those before treatment;in the observation group,the blood flow velocity of ACA,MCA and PCA were (46.89±3.15),(53.17±4.17) and (41.28±3.61) cm/s,which were significantly higher than (43.94±3.77),(50.26±3.58) and (38.15±3.57) cm/s in the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion In patients with VaD after cerebral infarction,the clinical effect of Guhong injection combined with idibenone is more significant than that of idibenone alone.The cognitive function,hemorheology and cerebral artery flow velocity are significantly improved,and the safety is good.
Cerebral infarctionVascular dementiaGuhong injectionIdibenoneCognitive function
万方数据
维普
