Effects of tripterygium glycosides combined with dapagliflozin on microalbuminuria and inflammatory factor levels in patients with type 2 diabetic nephropathy
Objective To explore the effects of tripterygium glycosides combined with dapagliflozin on microalbuminuria and inflammatory factor levels in patients with type 2 diabetic nephropathy.Methods 70 patients with type 2 diabetic nephropathy were divided into a conventional group and a combined group by random number table method,with 35 cases in each group.The conventional group was treated with dapagliflozin,and the combined group was treated with tripterygium glycosides and dapagliflozin.The clinical efficacy,immune function indicators,urea nitrogen and 24 h urinary protein quantification,oxidation factor and inflammatory factor were compared between the two groups.Results The total effective rate of the combined group was significantly higher than that of the conventional group (x2=4.629,P=0.031<0.05).After treatment,the combined group had CD4+of (48.56±4.58)％,CD8+of (19.86±2.45)％,and CD4+/CD8+of (2.78±0.33),which were significantly better than (42.93±4.69)％,(24.52±3.25)％,and (1.86±0.22) in the conventional group (P<0.05).The levels of urea nitrogen before and after treatment were (7.26±0.78) and (7.15±0.75) mmol/L in the conventional group,and (7.28±0.82) and (6.30±0.71) mmol/L in the combined group.Before treatment,there was no significant difference in urea nitrogen levels between the two groups (t=0.105,P=0.917>0.05).After treatment,the urea nitrogen level of the combined group was significantly lower than that of the conventional group (t=4.869,P=0.000<0.05).The levels of 24 h urinary protein quantification before and after treatment were (3.81±0.42) and (3.26±0.41) g/24 h in the conventional group,and (3.85±0.40) and (2.21±0.23) g/24 h in the combined group.Before treatment,there was no significant difference in 24 h urinary protein quantification between the two groups (t=0.408,P=0.685>0.05).After treatment,the 24 h urinary protein quantitative in the combined group was significantly lower than that in the conventional group (t=13.214,P=0.000<0.05).After treatment,the combined group had significantly higher SOD of (95.50±10.22) U/ml than (78.96±8.25) U/ml in the conventional group,and significantly lower malondialdehyde (MDA) of (19.65±2.20) μmol/L than (25.96±3.52) μmol/L in the conventional group (P<0.05).After treatment,the combined group had monocyte chemoattractant protein-1 (MCP-1) of (235.69±28.69) ng/L,interleukin-6 (IL-6) of (7.26±0.35) ng/L and tumor necrosis factor-α (TNF-α) of (9.63±1.02) ng/L,which were significantly lower than (276.20±32.45),(9.88±0.26) and (12.48±1.33) ng/L in the conventional group (P<0.05).Conclusion Tripterygium glycosides combined with dapagliflozin has significant clinical efficacy in patients with type 2 diabetic nephropathy,which can effectively reduce inflammatory response,improve immune function and clinical symptoms,and is worthy of clinical promotion.
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