Evaluation of the effect of tamsulosin,solifenacin and diclofenac sodium sustained-release tablets alone and in combination on lower urinary tract symptoms in patients with indwelling double-J stent after urolithiasis surgery
Objective To analyze the effect of tamsulosin,solifenacin and diclofenac sodium sustained-release tablets alone and in combination on lower urinary tract symptoms in patients with indwelling double-J stent after urolithiasis surgery.Methods 210 patients with indwelling double-J stent after surgery for urinary calculi were divided into control group A (oral tamsulosin),control group B (oral solifenacin),control group C (oral diclofenac sodium sustained-release tablets),observation group A (oral tamsulosin and solifenacin),observation group B (oral tamsulosin and diclofenac sodium sustained-release tablets),observation group C (oral solifenacin and diclofenac sodium sustained-release tablets),and observation group D (oral tamsulosin,solifenacin and diclofenac sodium sustained-release tablets),each with 30 cases.The bladder storage symptoms,lumbago and hematuria of the seven groups were compared.Results There was no statistically significant difference in the comparison of Overactive Bladder Symptom Score (OABSS) scores and Visual Analogue Scale (VAS) scores of control group A,control group B,and control group C at 3 d postoperatively,1 week postoperatively,and 2 weeks postoperatively (P>0.05).Comparison of OABSS score and VAS score in observation group A,observation group B and observation group C at 3 d postoperatively,1 week postoperatively and 2 weeks postoperatively were not statistically significant (P>0.05).OABSS score and VAS score of observation group A,observation group B,observation group C and observation group D were lower than those of control group A,control group B and control group C at 3 d postoperatively,1 week postoperatively and 2 weeks postoperatively,and the differences were statistically significant (P<0.05).OABSS score and VAS score of observation group D were lower than those of observation group A,observation group B and observation group C at 3 d postoperatively,1 week postoperatively and 2 weeks postoperatively,and the differences were statistically significant (P<0.05).The incidence of hematuria of 3.33％ in observation group D was significantly lower than 20.00％ in control group A,20.00％ in control group B and 23.33％ in control group C.The difference was statistically significant (P<0.05).Comparison of the incidence of hematuria in control group A,control group B,control group C and observation group A,observation group B,observation group C showed no statistically significant difference (P>0.05).The difference in the incidence of hematuria was not statistically significant when compared among observation group A,observation group B,observation group C and observation group D (P>0.05).Conclusion The combination of tamsulosin,solifenacin and diclofenac sodium sustained-release tablets can effectively improve the lower urinary trac symptomst and reduce the risk of hematuria in patients with indwelling double-J stent after urolithiasis surgery,and the value of the combination was higher than that of monotherapy.
万方数据
维普
