Study on the correlation of vitamin D and serum hepcidin with iron deficiency anemia in pregnant women and their offspring
Objective To explore the correlation of vitamin D and serum hepcidin with iron deficiency anemia (IDA) in pregnant women and their offspring.Methods 60 pregnant women with IDA who were hospitalized for delivery were retrospectively selected as the observation group,and another 60 pregnant women who were excluded from IDA during the same period in our hospital were selected as the control group.The observation group was randomly divided into the general treatment group (30 cases,iron supplementation) and the vitamin D treatment group (30 cases,iron supplementation+vitamin D).The clinical data,25 hydroxyvitamin D[25(OH)D],serum hepcidin levels were compared between the observation group and the control group;the levels of 25(OH)D,serum hepcidin and ferritin of pregnant women in the general treatment group and vitamin D treatment group were compared at different times after treatment,and the correlation of 25(OH)D and serum ferritin with hemoglobin (Hb) was analyzed by Pearson correlation analysis;the occurrence of IDA was compared between the observation group and the control group.Results Comparison of age,education,gestational week of delivery and mode of delivery between the observation group and the control group showed no statistically significant differences (P>0.05).The observation group had Hb of (101.56±6.29) g/L,ferritin of (10.21±2.05) µg/L,25(OH)D of (12.69±2.53) ng/ml,serum hepcidin of (30.81±6.16) ng/ml,which were lower than (117.93±6.85) g/L,(38.94±7.79) µg/L,(34.07±6.82) ng/ml and (47.52±9.44) ng/ml in the control group.After 2,4 and 8 weeks of treatment,the serum hepcidin and ferritin levels in the general treatment group,and 25(OH)D,serum hepcidin and ferritin levels in the vitamin D treatment group showed a significant trend of elevation,and the 25(OH)D,serum hepcidin and ferritin levels in the vitamin D treatment group were significantly higher than those in the general treatment group (P<0.05).Pearson analysis showed that 25(OH)D,serum hepcidin levels and Hb levels were positively correlated (P<0.001).The incidence of IDA in newborns in the observation group were 3.33％ and 6.67％ at birth and 1 month after birth,which were slightly lower than 11.67％ and 16.67％ in the control group,but the difference was not statistically significant (P>0.05).Conclusion Vitamin D and serum hepcidin levels are correlate with the severity of IDA in pregnant women,and deficiencies in both can increase the risk of IDA in pregnant women and their offspring,which should be monitored and taken seriously in clinical practice.
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