Analysis of clinical effect of flurbiprofen axetil combined with dexmedetomidine intensive anesthesia on postoperative pain in patients undergoing thyroid surgery
Objective To explore the clinical effect of flurbiprofen axetil combined with dexmedetomidine intensive anesthesia on postoperative pain in patients undergoing thyroid surgery.Methods 162 patients undergoing thyroid surgery were selected as the study subjects,and the patients were divided into a control group and a study group by random number table method,with 81 cases in each group.The control group received dexmedetomidine for intensive anesthesia,and the study group received flurbiprofen axetil for intensive anesthesia on the basis of the control group.Patients in both groups were compared in terms of vital signs at different time points[basic value of venous access (T0),after completion of surgery (T1)],pain and sedation score at different time points[2 h postoperatively (T2),4 h postoperatively (T3),8 h postoperatively (T4),and 12 h postoperatively (T5)],anesthesia recovery time,and adverse reactions.Results In the study group,the differences in mean arterial pressure,pulse oxygen saturation,and respiratory rate at T1 were not statistically significant when compared to that at T0 (P>0.05).There was no significant difference in respiratory rate at T1 in the control group when compared with that at T0 in this group and that at T1 in the study group (P>0.05).However,the mean arterial pressure of (66.56±7.15) mm Hg (1 mm Hg=0.133 kPa) and pulse oxygen saturation of (82.28±10.87)％ in the control group were significantly lower than (78.55±8.27) mm Hg and (98.64±10.13)％ at T0 in this group,and (78.29±8.52) mm Hg and (96.32±10.88)％ at T1 in the study group.The difference was statistically significant (P<0.05).In the study group,the pain scores at T2,T3,T4,T5 were (2.41±0.36),(2.25±0.32),(1.67±0.30),(1.67±0.30) points,the sedation scores were (2.16±0.29),(2.14±0.26),(1.89±0.20),(1.46±0.18) points,which were significantly lower than (2.96±0.48),(2.93±0.46),(2.93±0.43),(2.91±0.38) points and (2.86±0.46),(2.78±0.40),(2.14±0.24),(2.10±0.21) points in the control group.The difference was statistically significant (P<0.05).There was no significant difference in anesthesia recovery time between the two groups (t=1.451,P=0.149>0.05).There was no significant difference in the incidence of adverse reactions between the two groups (x2=0.228,P=0.633>0.05).Conclusion The application of flurbiprofen axetil combined with dexmedetomidine intensive anesthesia for patients undergoing thyroid surgery can significantly reduce the degree of pain and suffering without affecting the patients' recovery time and vital signs,and the clinical safety is good,which is worthy of popularization and use.
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