Analysis of the clinical significance of hematocrit,procalcitonin,and albumin detection on the severity and prognosis of acute pancreatitis
Objective To analyze the clinical significance of hematocrit,procalcitonin,and albumin detection on the severity and prognosis of acute pancreatitis.Methods A total of 146 patients with acute pancreatitis were selected and divided into an observation group(80 cases)and a control group(66 cases)based on the severity of their condition.The patients were divided into good prognosis group(134 cases)and bad prognosis group(12 cases)according to the different prognosis of 28 d of follow-up.The levels of albumin,procalcitonin and hematocrit were compared between the observation group and the control group,the good prognosis group and the poor prognosis group.The predictive value of albumin,procalcitonin and hematocrit alone and in combination in patients with acute pancreatitis was analyzed.Results The observation group had albumin of(35.12±7.22)g/L and hematocrit of(39.55±7.30)%,which were lower than(39.44±6.23)g/L and(41.71±4.36)%in the control group;the procalcitonin of(2.16±0.11)ng/ml in the observation group was higher than(0.91±0.05)ng/ml in the control group;the difference was significant(P<0.05).The poor prognosis group had albumin of(34.05±4.22)g/L and hematocrit of(34.26±6.23)%,which were lower than(37.34±4.56)g/L and(41.09±5.22)%in the good prognosis group;the procalcitonin of(3.52±0.13)ng/ml in the poor prognosis group was higher than(1.42±0.06)ng/ml in the good prognosis group;the difference was significant(P<0.05).The cut-off point of procalcitonin in predicting the severity of acute pancreatitis was 1.78 ng/ml,the area under the curve(AUC)was 0.886,with a specificity and sensitivity of 93.12%and 79.52%;the cut-off point of albumin was 36.43 g/L,AUC was 0.876,with a specificity and sensitivity of 93.08%and 78.86%;the cut-off point of hematocrit was 36.78%,AUC was 0.678,with a specificity and sensitivity of 48.23%and 72.11%.The cut-off point of hematocrit in predicting poor prognosis of acute pancreatitis was 35.86%,AUC was 0.771,with a specificity and sensitivity of 85.02%and 68.78%;the cut-off point of procalcitonin was 1.98 ng/ml,AUC was 0.819,with a specificity and sensitivity of 89.29%and 74.36%;the cut-off point of albumin was 35.61 mg/L,AUC was 0.813,with a specificity and sensitivity of 88.51%and 74.12%.The AUC of the combined detection of the three indicators was 0.921,with a specificity and sensitivity of 96.02%and 71.20%.The combined detection of the three indicators was better than albumin,procalcitonin and hematocrit alone in predicting the poor prognosis of acute pancreatitis.Conclusion Serum albumin and procalcitonin are more accurately to assess the severity of acute pancreatitis,and the combined detection of these three indicators can provide accurate predictive information for the risk of poor prognosis in patients with acute pancreatitis.
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