The effect of inducing labor at different time points after rupture of membranes in women with premature rupture of membranes at term on the course of labor and maternal and infant outcomes
Objective To observe the effect of inducing labor at different time points after rupture of membranes in women with premature rupture of membranes(PROM)at term on the course of labor and maternal and infant outcomes.Methods All 180 women with PROM at term were given oxytocin to induce labor,and were divided into Group A(labor induction within 2-12 h after rupture of membranes,96 cases)and Group B(labor induction>12 h after rupture of membranes,84 cases)based on the timing of induction of labor.Group A and Group B could be further subdivided into Group A1(Bishop score≥6 points,59 cases),Group A2(Bishop score<6 points,37 cases),Group B1(Bishop score≥6 points,32 cases)and Group B2(Bishop score<6 points,52 cases).The time from rupture of membranes to delivery,total duration of labor,mode of delivery,adverse pregnancy outcome and neonatal complication rate of the four groups were compared.Results Time from rupture of membranes to delivery:Group A1(11.33±3.15)h was significantly shorter than Group A2(19.49±6.58)h,Group B1(17.78±4.28)h,and Group B2(19.64±6.85)h(P<0.05),and there was no statistically significant difference in comparison of every two groups of Group A2,Group B1,and Group B2(P>0.05).Total duration of labor:Group A1(6.43±2.11)h and Group B1(6.28±1.97)h were significantly shorter than Group A2(9.56±2.43)h and Group B2(9.39±2.20)h(P<0.05),and there was no statistically significant difference in the comparison between Group A1 and Group B1,and Group A2 and Group B2(P>0.05).Cesarean section rate:Group A2(64.86%)was significantly higher than Group A1(27.12%),Group B1(25.00%),and Group B2(40.38%)(P<0.05),and there was no statistically significant difference in comparison of every two groups of Group A1,Group B1 and Group B2(P>0.05).The incidence of adverse pregnancy outcomes:Group A1(3.39%)was the lowest,followed by Group B2(7.69%),and both were significantly lower than Group A2(24.32%)and Group B1(25.00%)(P<0.05).There was no statistical difference between Group A1 and Group B2,and Group A2 and Group B1(P>0.05).The incidence of neonatal complications:Group A1(5.07%)was the lowest,followed by Group B2(7.69%),and both were significantly lower than Group A2(29.73%)and Group B1(25.00%)(P<0.05).There was no statistical difference between Group A1 and Group B2,and Group A2 and Group B1(P>0.05).Conclusion For women with PROM at term,labor induction within 2-12 h after rupture of membranes for those with high cervical maturity and 12 h after rupture of membranes for those with low cervical maturity is more conducive to shortening the duration of labor and improving the outcome of mothers and infants,providing a basis for clinical exploration of the optimal timing of labor induction.
Premature rupture of membranesStage of laborTiming of induction of laborCervical ripenessMaternal and infant outcomes
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