Effect of modified electroconvulsive therapy on serum indicators and cognitive function in patients with schizophrenia
Objective To explore the effect of modified electroconvulsive therapy on serum indicators and cognitive function in patients with schizophrenia.Methods A total of 100 patients with schizophrenia were selected as research subjects and randomly divided into the study group(50 enrolled cases,9 drop-out cases,41 completed cases)and the control group(50 enrolled cases,7 drop-out cases,43 completed cases).The study group was treated with conventional drugs combined with MECT,and the control group was treated with conventional drugs.Patients in both groups were compared in terms of serum levels of brain-derived neurotrophic factor(BDNF),interleukin-6(IL-6),positive and negative symptom scale(PANSS)score and repeatable battery for the assessment of neuropsychological status(RBANS)score before and after treatment,and the incidence of adverse reactions.Results Before treatment,there were no significant differences in serum BDNF,IL-6 levels and PANSS and RBANS scores between the two groups(P>0.05).After 8 weeks of treatment,the serum BDNF level was higher than that before treatment,and IL-6 level was lower than that before treatment;the serum BDNF level of 24.56(17.00,34.26)ng/ml in the study group was significantly higher than 18.67(14.79,24.56)ng/ml in the control group;IL-6 of 8.70(2.55,13.17)pg/ml in the study group was lower than 15.87(3.93,24.01)pg/ml in the control group(P<0.05).After 8 weeks of treatment,RBANS scores were significantly higher and PANSS scores in both groups were significantly lower than those before treatment;RBANS score of(72.44±4.63)points in the study group was significantly higher than(66.19±9.40)points in the control group;PANSS score of(54.88±9.58)points in the study group was significantly lower than(75.02±11.53)points in the control group(P<0.05).The incidence of adverse reactions in the study group was 7.32%,which was significantly lower than 25.58%in the control group(P<0.05).Conclusion MECT can increase serum BDNF level and decrease IL-6 level in patients with schizophrenia,and significantly improve the cognitive function of patients with high safety.
Modified electroconvulsive therapySchizophreniaBrain-derived neurotrophic factorInflammatory factorsCognitive function
NETL
NSTL
万方数据
