Exploring the efficacy of noninvasive ventilator in combination with invasive mechanical ventilation in the treatment of respiratory failure
Objective To explore the efficacy of noninvasive ventilator in combination with invasive mechanical ventilation in the treatment of respiratory failure.Methods 60 patients with respiratory failure were selected as the study subjects,and the patients were divided into a control group and an observation group by random numerical table,with 30 cases in each group.The control group was treated with invasive mechanical ventilation,while the observation group was treated with noninvasive ventilator+invasive mechanical ventilation.The therapeutic effect,stress indicators,respiratory and indicators of cardio-pulmonary function,and the incidence of ventilator-related adverse reactions were compared between the two groups.Results The total effective rate of 96.67%in the observation group was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the heart rate was(84.39±4.11)beats/min,the respiratory rate was(21.14±1.96)times/min,and the arterial partial pressure of carbon dioxide was(43.92±2.21)mm Hg(1 mm Hg=0.133 kPa),which were lower than(113.02±5.43)beats/min,(27.39±2.87)times/min,and(58.29±3.98)mm Hg in the control group;the blood oxygen saturation was(95.22±5.36)%,the arterial partial pressure of oxygen was(95.82±6.43)mm Hg,and pH value was(7.49±0.13),which were higher than(86.29±5.11)%,(86.99±5.43)mm Hg,and(7.19±0.09)in the control group;the difference was statistically significant(P<0.05).In the observation group,the angiotensin Ⅱ was(31.29±3.11)pg/ml,the renin activity was(2.21±0.34)ng/(ml·h),the norepinephrine was(131.02±15.54)ng/ml,and the epinephrine(97.22±5.73)ng/ml,which were lower than(56.56±5.44)pg/ml,(4.19±0.76)ng/(ml·h),(199.98±19.47)ng/ml,and(158.43±9.87)ng/ml in the control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of ventilator-related adverse reactions was 3.33%in the observation group,which was lower than 33.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion The efficacy of non-invasive ventilator+invasive mechanical ventilation in patients with respiratory failure is remarkable,and the patients'stress indicators,and indicators of cardio-pulmonary function have been effectively improved,and the incidence of ventilator-related adverse reactions is low,which is of significant clinical application value.
NETL
NSTL
万方数据
