Clinical efficacy analysis of atorvastatin combined with trimetazidine in the treatment of coronary heart disease
Objective To explore the effect of atorvastatin combined with trimetazidine in the treatment of coronary heart disease.Methods 60 patients with coronary heart disease were divided into a control group and an observation group using a random number table method,each consisting of 30 patients.The control group received treatment with trimetazidine on the basis of conventional treatment,while the observation group received treatment with atorvastatin on the basis of the control group.The clinical effects,cardiac function indicators[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],and hemorheological indicators(whole-blood low-shear viscosity,whole-blood high-shear viscosity,plasma viscosity)were compared between the two groups.Results The total effective rate of the observation group and the control group were 93.33%and 73.33%,respectively,and the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the plasma viscosity of the control group was(1.63±0.05)mPa·s,the whole-blood low-shear viscosity was(9.12±0.42)mPa·s,and the whole-blood high-shear viscosity was(6.15±0.24)mPa·s;the plasma viscosity of the observation group was(1.45±0.04)mPa·s,the whole-blood low-shear viscosity was(7.36±0.22)mPa·s and the whole-blood high-shear viscosity was(5.22±0.17)mPa·s;the observation group was lower than the control group(P<0.05).Compared with LVEF of(41.62±9.42)%,LVEDD of(63.30±7.21)mm and LVESD of(51.24±8.10)mm in the control group,the observation had higher LVEF of(47.69±12.08)%,and smaller LVEDD of(59.38±6.65)mm and LVESD of(46.53±7.27)mm after treatment(P<0.05).Conclusion The treatment of atorvastatin+trimetazidine in patients with coronary heart disease can achieve definite clinical efficacy and help improve the cardiac function indicators and hemorheological indicators.
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