The value of combined detection of PCT,PA,CRP and WBC in the diagnosis of infectious diseases in children
Objective To analyze the diagnostic value of combined detection of procalcitonin (PCT),prealbumin (PA),C-reactive protein (CRP) and white blood cell count (WBC) in children with infectious diseases. Methods 97 children with infectious diseases were included as the study subjects. According to the pathogenic results,they were divided into bacterial infection group (46 cases) and non-bacterial infection group (51 cases),and another 50 healthy children were selected as the control group. The PCT,PA,CRP,and WBC levels and positive rates of the three groups were tested and compared;the diagnostic results of individual and combined detection of PCT,PA,CRP and WBC for bacterial infections were analyzed;the diagnostic efficacy of individual and combined detection of PCT,PA,CRP,and WBC were compared. Results The bacterial infection group had PCT of (4.56±1.03) ng/ml,CRP of (92.64±48.71) mg/L and WBC of (16.37±4.15)×109/L,which were all higher than (0.44±0.14) ng/ml,(7.53±2.61) mg/L and (9.16±3.68)×109/L in the non-bacterial infection group,and (0.39±0.11) ng/ml,(6.70±2.19) mg/L and (6.82±2.88)×109/L in the control group;the bacterial infection group had lower PA of (102.60±24.43) mg/L than (252.24±45.43) mg/L in the non-bacterial infection group,and (265.69±82.24) mg/L in the control group (P<0.05). WBC in the non-bacterial infection group was significantly higher than that in the control group (P<0.05). There was no difference in the comparison of PCT,CRP and PA between the control group and the non-bacterial infection group (P>0.05). The positive rates of PCT,PA,CRP and WBC in the bacterial infection group were higher than those in the non-bacterial infection group and the control group (P<0.05). The positive rates of PCT,PA,CRP and WBC in the non-bacterial infection group were not different from those in the control group (P>0.05). The sensitivity,specificity,positive predictive value and negative predictive value of combined detection were 93.48％,92.16％,91.49％ and 94.00％,those of PCT alone were 69.57％,76.47％,72.73％,73.58％,those of PA alone were 65.22％,74.51％,69.77％,70.37％,those of CRP alone were 60.87％,76.47％,70.00％ and 68.42％,and those of WBC alone were 52.17％,72.55％,63.16％ and 62.71％. The sensitivity,specificity,positive predictive value and negative predictive value of combined detection were higher than those of PCT,PA,CRP and WBC alone (P<0.05). Conclusion Combined detection of PCT,PA,CRP,and WBC is beneficial for diagnosing bacterial infections in children,and can significantly improve the diagnostic efficacy,which can be applied to guide the use of antibiotics.
万方数据
维普
