A study on the value of hs-CRP,PCT,GLB and PA tests in the diagnosis of pediatric bacterial infections
Objective To explore the value of hypersensitive C-reactive protein (hs-CRP),procalcitonin (PCT),globulin (GLB) and prealbumin (PA) tests in the diagnosis of pediatric bacterial infections. Methods 125 children with acute respiratory tract infections were divided into bacterial infection group (75) and viral infection group (50) based on their symptomatic manifestations,signs,laboratory and pathogenetic test results. All children received hs-CRP,PA,PCT,GLB test. Using the test results as the gold standard,the diagnostic efficacy (sensitivity,specificity and accuracy) of hs-CRP,PA and PCT alone and in combination for pediatric bacterial infection were compared. Results At the time of admission,the blood hs-CRP of the bacterial infection group was (12.38±2.14) mg/L and PCT was (2.45±0.84) ng/ml,which were higher than (8.58±1.57) mg/L and (0.78±0.22) ng/ml in the viral infection group;the bacterial infection group had lower PA of (102.55±16.24) mg/L than (163.25±20.33) mg/L in the bacterial infection group (P<0.05). PA of (102.55±16.24) mg/L in the bacterial infection group was lower than (163.25±20.33) mg/L in the viral infection group (P<0.05). The GLB levels of children in the two groups were basically the same (P>0.05). The diagnostic sensitivity,specificity and accuracy of hs-CRP test for pediatric bacterial infections were 90.7％,86.0％ and 88.8％;the diagnostic sensitivity,specificity and accuracy of PA test for pediatric bacterial infections were 85.3％,78.0％ and 82.4％;the diagnostic sensitivity,specificity and accuracy of PCT test for pediatric bacterial infections were 90.7％,86.0％ and 88.8％;the diagnostic sensitivity,specificity and accuracy of combined tests were 98.7％,98.0％ and 98.4％. The sensitivity,specificity and accuracy of the combined tests were higher than those of hs-CRP,PA and PCT test alone (P<0.05). The area under the curve (AUC) of combined tests was 0.971,which was higher than 0.801,0.744 and 0.792 of hs-CRP,PA and PCT test alone. Conclusion The combined detection of hs-CRP,PA and PCT in the diagnosis of pediatric bacterial infections has good efficacy,and can help to improve the clinical diagnosis and treatment effect.
万方数据
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