Analysis of the application value of glycosylated hemoglobin and β2-microglobulin tests in diabetic patients
Objective To analyze the clinical value of glycosylated hemoglobin and β2-microglobulin tests in diabetic patients. Methods 70 diabetic patients and 70 healthy subjects were selected and set as the study group and the control group. Glycosylated hemoglobin,β2-microglobulin,and fasting blood glucose were tested in all subjects,and the levels of glycosylated hemoglobin,β2-microglobulin,and fasting blood glucose were compared between the two groups;the levels of glycosylated hemoglobin and β2-microglobulin were compared among patients with different disease duration in the study group;the positive rate of β2-microglobulin was compared between the two groups. Results In the study group,the glycosylated hemoglobin was (8.558±1.942)％,the β2-microglobulin was (9.140±1.269) mg/L,and the fasting blood glucose was (10.160±2.725) mmol/L,which were higher than (5.501±0.329)％,(2.340±1.069) mg/L,and (5.103±0.632) mmol/L in the control group (P<0.05). There was no difference in the comparison of glycosylated hemoglobin and β2-microglobulin levels between patients with a disease duration of<5 years and 5-10 years in the study group (P>0.05). The glycosylated hemoglobin of patients with a disease duration of>10 years was (11.124±3.630)％ and the β2-microglobulin was (10.500±1.496) mg/L,which were higher than (7.882±2.483)％ and (8.923±0.773) mg/L of patients with a disease duration of<5 years,and (9.126±2.827)％ and (9.216±1.014) mg/L of patients with a disease duration of 5-10 years (P<0.05). The positive rate of β2-microglobulin of 95.71％ in the study group was higher than 8.57％ in the control group (P<0.05). Conclusion For diabetic patients,the glycosylated hemoglobin and β2-microglobulin test can analyze the recent blood glucose situation of patients in detail,which is conducive to the adjustment of drug treatment plan. In addition,β2-microglobulin level can also effectively evaluate the renal microangiopathy of patients,which plays an important role in the diagnosis of diabetic nephropathy,and can achieve the effect of early diagnosis and treatment.
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