摘要
目的 分析糖化血红蛋白、β2-微球蛋白检测对糖尿病患者的临床价值.方法 选取70例糖尿病患者和同期70例健康人员分别作为研究组和对照组.对所有受试者糖化血红蛋白、β2-微球蛋白、空腹血糖进行检测,比较两组糖化血红蛋白、β2-微球蛋白、空腹血糖水平以及研究组不同病程患者的糖化血红蛋白、β2-微球蛋白水平,比较两组 β2-微球蛋白阳性率.结果 研究组的糖化血红蛋白(8.558±1.942)％、β2-微球蛋白(9.140±1.269)mg/L、空腹血糖(10.160±2.725)mmol/L与对照组的(5.501±0.329)％、(2.340±1.069)mg/L、(5.103±0.632)mmol/L比较均升高(P<0.05).研究组病程<5年、5～10年患者的糖化血红蛋白、β2-微球蛋白水平比较无差异(P>0.05);病程>10年患者的糖化血红蛋白(11.124±3.630)％、β2-微球蛋白(10.500±1.496)mg/L与病程<5年的(7.882±2.483)％、(8.923±0.773)mg/L以及5～10年的(9.126±2.827)％、(9.216±1.014)mg/L比较均升高(P<0.05).研究组β2-微球蛋白阳性率95.71％与对照组的8.57％比较更高(P<0.05).结论 对糖尿病患者进行β2-微球蛋白水平与糖化血红蛋白水平检测,能对患者近期内的血糖情况进行详细分析,有利于药物治疗方案的调整.且β2-微球蛋白水平也能有效评估患者的肾脏微血管病变情况,对糖尿病肾病的诊断具有重要作用,能达到尽早诊断、尽早治疗的目的.
Abstract
Objective To analyze the clinical value of glycosylated hemoglobin and β2-microglobulin tests in diabetic patients. Methods 70 diabetic patients and 70 healthy subjects were selected and set as the study group and the control group. Glycosylated hemoglobin,β2-microglobulin,and fasting blood glucose were tested in all subjects,and the levels of glycosylated hemoglobin,β2-microglobulin,and fasting blood glucose were compared between the two groups;the levels of glycosylated hemoglobin and β2-microglobulin were compared among patients with different disease duration in the study group;the positive rate of β2-microglobulin was compared between the two groups. Results In the study group,the glycosylated hemoglobin was (8.558±1.942)％,the β2-microglobulin was (9.140±1.269) mg/L,and the fasting blood glucose was (10.160±2.725) mmol/L,which were higher than (5.501±0.329)％,(2.340±1.069) mg/L,and (5.103±0.632) mmol/L in the control group (P<0.05). There was no difference in the comparison of glycosylated hemoglobin and β2-microglobulin levels between patients with a disease duration of<5 years and 5-10 years in the study group (P>0.05). The glycosylated hemoglobin of patients with a disease duration of>10 years was (11.124±3.630)％ and the β2-microglobulin was (10.500±1.496) mg/L,which were higher than (7.882±2.483)％ and (8.923±0.773) mg/L of patients with a disease duration of<5 years,and (9.126±2.827)％ and (9.216±1.014) mg/L of patients with a disease duration of 5-10 years (P<0.05). The positive rate of β2-microglobulin of 95.71％ in the study group was higher than 8.57％ in the control group (P<0.05). Conclusion For diabetic patients,the glycosylated hemoglobin and β2-microglobulin test can analyze the recent blood glucose situation of patients in detail,which is conducive to the adjustment of drug treatment plan. In addition,β2-microglobulin level can also effectively evaluate the renal microangiopathy of patients,which plays an important role in the diagnosis of diabetic nephropathy,and can achieve the effect of early diagnosis and treatment.
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