Evaluation on clinical effect of dapagliflozin combined with spironolactone and metoprolol in the treatment of heart failure
Objective To explore the clinical effect of dapagliflozin combined with spironolactone and metoprolol in the treatment of heart failure (HF). Methods 150 patients with heart failure were selected as the study subjects,all patients were divided into a conventional group and a study group,each with 75 patients. The conventional group was treated with spironolactone combined with metoprolol,and the study group was treated with dapagliflozin based on the conventional group. Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular end-systolic volume (LVESV),left ventricular ejection fraction (LVEF),left ventricular end-diastolic volume (LVEDV)]and neuroendocrine factors[angiotensin Ⅱ (AngⅡ),aldosterone (ALD),N-terminal pro-B-type natriuretic peptide (NT-proBNP)]after 3 months of treatment,and occurrence of adverse reactions. Results The overall clinical efficacy of 98.67％ in the study group was significantly higher than 85.33％ in the conventional group (P<0.05). After 3 months of treatment,the study group had LVESV of (70.26±8.19) ml and LVEDV of (125.78±18.66) ml,which were significantly lower than (78.58±8.94) and (138.44±20.31) ml in the conventional group;LVEF of (40.98±5.21)％ in the study group was significantly higher than (32.29±4.22)％ in the conventional group (P<0.05). After 3 months of treatment,the levels of AngⅡ,ALD and NT-proBNP of the study group were (65.93±8.22) pg/ml,(552.78±135.98) pmol/L and (797.62±55.23) pg/ml,which were significantly lower than (82.68±5.81) pg/ml,(842.53±141.56) pmol/L and (886.95±62.54) pg/ml of the conventional group (P<0.05). The incidence of adverse reactions in the study group was 4.00％,which had no significant difference compared with 2.67％ in the conventional group (P>0.05). Conclusion Dapagliflozin combined with spironolactone and meetoprolol can enhance the therapeutic effect of patients with heart failure,and have good safety.
万方数据
维普
