Clinical value of benazepril combined with nifedipine in the treatment of elderly patients with hypertensive heart disease
Objective To analyze the clinical value of benazepril combined with nifedipine in the treatment of elderly patients with hypertensive heart disease (HHD). Methods 50 elderly patients with HHD as observation subjects were divided into an observation group (25 cases) and a control group (25 cases) by random number table method. The control group was treated with nifedipine on the basis of conventional treatment,and the observation group was treated with benazepril on the basis of the control group. Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular end-diastolic diameter (LVEDd),ratio of early transmitral flow velocity to later transmitral flow velocity (E/A),left ventricular ejection fraction (LVEF)]and exercise capacity indicators[metabolic equivalents (METs),maximal oxygen consumption (VO2max),6-min walking distance (6MWD)]before and after treatment. Results The total effective rate of 92.0％ in the observation group was higher than 68.0％ in the control group,and there was statistical difference (P<0.05). After treatment,LVEDd in both groups was lower than that before treatment,and E/A and LVEF were higher than those before treatment;LVEDd of (52.36±3.16) mm in the observation group was smaller than (55.85±2.48) mm in the control group;the observation group had E/A of (1.11±0.04) and LVEF of (53.69±2.64)％,which were higher than (0.89±0.08) and (48.52±1.94)％ in the control group;there was statistical difference (P<0.05). After treatment,METs and VO2max in both groups were higher than those before treatment,and 6MWD was longer than that before treatment;the observation group had METs of (5.49±0.32) and VO2max of (24.58±2.64) ml/(kg·min),which were higher than (4.78±0.24) and (19.55±2.64) ml/(kg·min) in the control group;6MWD of (295.62±15.84) m in the observation group was longer than (245.63±13.85) m in the control group;there was statistical difference (P<0.05). Conclusion In elderly patients with HHD,the combination of benazepril and nifedipine on the basis of conventional treatment has a high therapeutic effect,which is conducive to improving the patients' cardiac function and exercise ability,and is more conducive to the rehabilitation of patients after treatment than conventional treatment,which is worthy of promotion and application.
BenazeprilNifedipineHypertensive heart diseaseOld age
万方数据
维普
