Effect of nSIMV combined with alveolar surfactant on blood gas indexes and clinical efficacy of premature infants with respiratory distress syndromea
Objective To explore the effect of nasal synchronized intermittent mandatory ventilation (nSIMV) combined with alveolar surfactant on blood gas indexes and clinical efficacy of premature infants with respiratory distress syndrome. Methods According to different treatment regimens,80 premature infants with respiratory distress syndrome were divided into an observation group (40 cases) and a control group (40 cases). The control group was treated with nSIMV,and the observation group was treated with alveolar surfactant of calf pulmonary surfactant for injection based on the control group. Both groups were compared in terms of clinical efficacy,blood gas indexes[arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2)]and respiratory related indexes[fractional inspired oxygen concentration (FiO2),peak inspiratory pressure (PIP),mean airway pressure (MAP)]. Results The total effective rate of 95.00％ in the observation group was higher than 80.00％ in the control group,and the difference was statistically significant (P<0.05). After 24 h of treatment,PaO2 and PaCO2 were improved in both groups;the observation group had higher PaO2 of (72.45±7.74) mm Hg (1 mm Hg=0.133 kPa) than (62.90±6.64) mm Hg in the control group,and lower PaCO2 of (45.08±5.41) mm Hg than (50.84±5.56) mm Hg in the control group;the difference was statistically significant (P<0.05). After 12 h of treatment,FiO2,PIP and MAP were improved in both groups;the observation group had FiO2 of (0.34±0.11),PIP of (20.22±1.89) cm H2O (1 cm H2O=0.098 kPa) and MAP of (10.21±0.98) cm H2O,which were lower than (0.47±0.15),(22.23±2.43) cm H2O and (11.29±1.24) cm H2O in the control group;the difference was statistically significant (P<0.05). Conclusion The combination of nSIMV and alveolar surfactant can improve the blood gas analysis and respiratory related indexes of premature infants with respiratory distress syndrome,and effectively improve clinical efficacy.
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维普
