Analysis of the application effect of carbetocin in preventing postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery
Objective To comprehensively evaluate the application effect of carbetocin in preventing postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery. Methods 100 high-risk women with vaginal delivery were divided into a control group and an observation group using a random numerical table,each consisting of 50 cases. The control group was treated with oxytocin,and the observation group was treated with carbetocin. Comparison was made on the duration of the third stage of labor,bleeding volume at 2 and 24 h postpartum,coagulation function indicators,decline in red blood cell and hemoglobin,postpartum blood pressure and heart rate,incidence of postpartum hemorrhage and adverse reactions between the two groups. Results The duration of the third stage of labor of (8.16±0.85) min in the observation group was shorter than (9.63±0.96) min in the control group;the observation group had bleeding volume of (190.48±56.11) ml at 2 h postpartum and (265.48±68.61) ml at 24 h postpartum,which were less than (232.49±69.93) and (342.00±75.56) ml in the control group (P<0.05). The observation group had postpartum prothrombin time (PT) of (11.58±2.31) s and activated partial thromboplastin time (APTT) of (28.96±3.84) s,which were shorter than (13.06±2.03) and (33.24±3.85) s in the control group;the fibrinogen (FIB) of (3.69±0.84) g/L in the observation group was higher than (3.25±0.37) g/L in the control group (P<0.05). The decline in red blood cell of the observation group was (0.41±0.05)×1012/L and the decline in hemoglobin was (6.52±1.43) g/L,which were lower than (0.63±0.10)×1012/L and (8.73±1.69) g/L of the control group (P<0.05). There were no significant differences in postpartum systolic blood pressure and diastolic blood pressure between the two groups (P>0.05). The postpartum heart rate of (86.19±2.67) beats/min in the observation group was lower than (92.59±2.55) beats/min in the control group (P<0.05). No postpartum hemorrhage occurred in both groups. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The proportion of other treatment was 10％ in the observation group,which was lower than 28％ in control group (P<0.05). Conclusion The use of carbetocin in high-risk women with vaginal delivery has positive significance,and can effectively improve postpartum hemorrhage,optimize delivery progress,thus improving the patient prognosis,which is worthy of clinical promotion and application.
万方数据
维普
