Study on value of methylprednisolone in emergency treatment of acute attacks of moderate to severe bronchial asthma
Objective To study the value of methylprednisolone sodium succinate for injection (methylprednisolone) in emergency treatment of acute attacks of moderate to severe bronchial asthma. Methods 116 patients with acute attack of moderate to severe bronchial asthma were selected and randomly divided into a control group and an observation group,with 58 cases in each group. The control group was treated with budesonide,and the observation group was treated with methylprednisolone. Comparison was made on therapeutic effect,pulmonary function[forced vital capacity (FVC),forced expiratory volume in one second (FEV1),peak expiratory flow (PEF)],blood gas index[arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2)],serum total immunoglobulin E (IgE) and eosinophil (EOS) count and quality of life between the two groups. Results In the observation group,55 cases (94.8％) were effective and 3 cases (5.2％) were ineffective;in the control group,38 cases (65.5％) were effective and 20 cases (34.5％) were ineffective. The effective rate of the observation group was higher than that of the control group (P<0.05). After treatment,the observation group had PEF of (6.15±0.27) L/s,FEV1 of (2.64±0.14) L and FVC of (2.93±0.11) L;the control group had PEF of (5.11±0.25) L/s,FEV1 of (1.82±0.12) L and FVC of (2.35±0.14) L. After treatment,PEF,FEV1 and FVC of the observation group were higher than those of the control group (P<0.05). After treatment,the observation group had PaO2 of (84.30±9.10) mm Hg (1 mm Hg=0.133 kPa) and PaCO2 of (34.10±2.10) mm Hg;the control group had PaO2 of (77.20±11.10) mm Hg and PaCO2 of (43.10±5.60) mm Hg. After treatment,PaO2 of the observation group was higher than that of the control group,and PaCO2 was lower than that of the control group (P<0.05). After treatment,the observation group had serum EOS count of (0.30±0.01)×109/L and total IgE of (106.80±.9.70) U/ml;the control group had serum EOS count of (0.40±0.21)×109/L and total IgE of (146.20±8.20) U/ml. After treatment,the serum EOS count and total IgE in the observation group were lower than those in the control group (P<0.05). After treatment,the scores of bodily function,role-emotional,general health,social functioning,mental health,physical functioning,vitality,and role-physical in the observation group were higher than those in the control group (P<0.05). Conclusion Choosing methylprednisolone in emergency treatment for acute attacks of moderate to severe bronchial asthma has achieved significant therapeutic effects and is feasible.
Moderate to severe bronchial asthmaAcute attackMethylprednisolone sodium succinate for injectionEfficacyBlood gas indicatorsPulmonary function
万方数据
维普
