Study on clinical effect of iron dextran oral solution combined with vitamin C in the treatment of iron deficiency anemia in children
Objective To explore the clinical effect of iron dextran oral solution combined with vitamin C in the treatment of iron deficiency anemia in children. Methods 86 children with iron deficiency anemia were randomly divided into a control group and an observation group,with 43 cases in each group. The control group was treated with iron dextran oral solution alone,and the observation group was treated with iron dextran oral solution combined with vitamin C. Comparison was made on clinical efficacy,blood routine indexes[red blood cell count (RBC),hemoglobin (Hb),mean corpuscular hemoglobin concentration (MCHC),mean corpuscular hemoglobin (MCH)],iron metabolism indexes[serum ferritin (SF),serum iron (SI),total iron binding capacity (TIBC),transferrin saturation (TSAT)]and adverse reactions between the two groups. Results The total effective rate of the observation group was 95.35％,which was significantly higher than 72.09％ of the control group (P<0.05). After treatment,the observation group had RBC of (4.15±0.76)×1012/L,Hb of (116.17±12.74) g/L,MCHC of (330.43±21.67) g/L,and MCH of (28.98±2.19) pg,which were higher than (3.23±0.57)×1012/L,(103.52±11.83) g/L,(305.79±20.58) g/L,and (25.60±2.36) pg in the control group (P<0.05). After treatment,the observation group had SF of (17.08±3.46) μg/L,SI of (12.10±2.41) μmol/L,and TSAT of (17.10±2.11)％,which were higher than (14.27±2.65) μg/L,(10.57±2.16) μmol/L,and (14.56±2.17)％ in the control group;the observation group had lower TIBC of (60.12±3.54) μmol/L than (66.73±4.01) μmol/L in the control group (P<0.05). The incidence of adverse reactions of 4.65％ in the observation group was significantly lower than 20.93％ in the control group (P<0.05). Conclusion Iron dextran oral solution combined with vitamin C has a significant clinical effect in the treatment of iron deficiency anemia in children,which can effectively correct blood routine indexes and improve iron metabolism,and has good safety.
Iron deficiency anemia in childrenIron dextran oral solutionVitamin CClinical effect
万方数据
维普
