Comparison of the efficacy and safety of acrivastine and levocetirizine in the treatment of atopic dermatitis
Objective To analyze the effect of acrivastine and levocetirizine in the treatment of atopic dermatitis. Methods A total of 62 patients with atopic dermatitis were randomly divided into a conventional group and a study group,with 31 cases in each group. The conventional group was treated with acrivastine,and the study group was treated with levocetirizine. The therapeutic effect,skin lesions,inflammatory indicators,pruritus severity,occurrence of adverse reactions and recurrence were compared between the two groups. Results Compared with 74.19％ in the conventional group,the total effective rate of 96.77％ in the study group was higher,and the difference was statistically significant (P<0.05). After treatment,the lesion severity score of the study group was (22.01±4.66) points,the lesion volume was (4.21±1.34) points,the sleep and pruritus score was (5.44±1.61) points and the total score was (31.66±6.41) points,which were lower than (26.84±5.23),(6.55±1.65),(7.12±2.24) and (40.51±7.55) points of the conventional group,and the difference was statistically significant (P<0.05). The study group had interleukin-4 of (10.85±2.61) ng/L,interleukin-13 of (26.26±7.01) ng/L,interleukin-17 of (24.15±6.65) ng/L,and interferon-γ (IFN-γ) of (15.88±2.23) ng/L,which were better than (13.57±3.94),(30.36±6.58),(28.86±7.46),and (13.86±2.44) ng/L in the conventional group,and the difference was statistically significant (P<0.05). The pruritus scores of the study group were (5.05±1.46),(2.03±0.85),and (1.24±1.06) points at 1,2,and 4 weeks after treatment,which were lower than (6.42±1.73),(4.64±1.75),and (3.12±1.34) points of the conventional group,and the difference was statistically significant (P<0.05). The incidence rate of adverse reactions in the study group was 6.45％,which was slightly lower than 12.90％ in the conventional group,but the difference was not statistically significant (P>0.05). The recurrence rate of 6.45％ in the study group was lower than 32.26％ in the conventional group,and the difference was statistically significant (P<0.05). Conclusion For patients with atopic dermatitis,levocetirizine can reduce the lesion severity,reduce the levels of inflammatory indicators of patients,and significantly relieve the pruritus severity of patients,and the treatment is effective and safe,which has clinical promotion significance.
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