Analysis of clinical effect of post-stroke depression treated by Jieyu Anshen acupuncture and its influence on sleep quality
Objective To study the clinical effect of post-stroke depression (PSD) treated by Jieyu Anshen acupuncture and its influence on sleep quality. Methods A total of 100 PSD patients were randomly divided into a control group and an observation group,with 50 cases in each group. The control group was treated with conventional treatment,and the observation group was treated with Jieyu Anshen acupuncture. The treatment effect and the level of inflammation,sleep quality,serum neurocytokine level,depression,daily living ability and neurological deficit were compared between the two groups. Results The total effective rate of 98.00％ in the observation group was higher than 76.00％ in the control group,and the difference was statistically significant (P<0.05). After treatment,the serum levels of brain-derived neurotrophic factor (BDNF),nerve growth factor (NGF),insulin-like growth factor-1 (IGF-1) and fibroblast growth factor-2 (FGF-2) in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05). After treatment,the levels of interleukin-1β (IL-1β),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the observation group were (71.36±8.35),(51.43±4.44) and (93.49±11.01) ng/L,which were lower than (96.70±6.36),(63.54±4.35) and (110.71±10.87) ng/L in the control group,and the differences were statistically significant (P<0.05). After treatment,the observation group had Hamilton Depression Scale (HAMD) score of (6.82±2.04) points and National Institutes of Health Stroke Scale (NIHSS) score of (9.86±3.06) points,which were lower than (14.25±4.22) and (15.39±4.29) points in the control group;the activities of daily living (ADL) score of (61.13±13.23) points in the observation group was higher than (49.25±14.43) points in the control group;the differences were statistically significant (P<0.05). After treatment,the subjective sleep quality score,sleep persistence score,sleep disorder score,and total score of the observation group were (0.82±0.16),(1.21±0.24),(0.77±0.14),and (2.59±0.46) points,which were lower than (1.30±0.25),(1.34±0.19),(1.16±0.20),and (4.83±0.67) points of the control group,and the differences were statistically significant (P<0.05). Conclusion Jieyu Anshen acupuncture for PSD patients can effectively improve the patients' depressive symptoms and sleep quality,and the therapeutic effect is remarkable,which is worthy of further promotion.
万方数据
维普
