Exploring the action mechanism of Tongqiao Erlong Pill in the treatment of vertigo based on network pharmacology and molecular docking
Objective To study the action mechanism of Tongqiao Erlong Pill in the treatment of vertigo based on network pharmacology and molecular docking. Methods TCMSP and other network data were used to obtain the effective components of Tongqiao Erlong Pill and its therapeutic targets for vertigo,constructed target-target and drug-target interaction networks. Analysis of the GO function and KEGG signaling pathway enrichment and molecular docking studies on the targets. Results There were 108 components from Tongqiao Erlong Pill interacting with 132 potential targets related to vertigo. These targets were mainly distributed in 8 pathways,including calcium signal,neuroactive ligand-receptor interaction,dopaminergic synapses,multiple neurodegenerative diseases,serotonin synapses,human cytomegalovirus infection,inflammatory mediator modulation of transient receptor potential (TRP) channels,lipids and atherosclerosis. Molecular docking calculations indicated that some of the active ingredients in Tongqiao Ear Deafness Pill had strong affinity to several key targets including serine/threonine-kinase 1 (AKT1),tumor necrosis factor (TNF),prostaglandin-endoperoxidase synthase 2 (PTGS2),angiotensin converting enzyme (ACE),angiotensin Ⅱ type 1 receptor (AGTR1),and calmodulin 1 (CALM1). Conclusion Tongqiao Erlong Pill can play a role in the treatment of vertigo by lowering blood pressure,reducing blood lipids,anti-inflammatory,antiviral,neuroprotective and other ways,and may deserve further development and research as an anti-vertigo drug.
万方数据
维普
