首页|丹栀逍遥散加六味地黄丸加减治疗失眠的疗效观察

丹栀逍遥散加六味地黄丸加减治疗失眠的疗效观察

扫码查看
目的 分析丹栀逍遥散加六味地黄丸加减治疗失眠患者的效果。方法 纳入 100 例失眠患者,以密闭信封法将纳入对象分为对照组(n=50)、研究组(n=50)。对照组采用六味地黄丸加减治疗,研究组在对照组基础上联合丹栀逍遥散加减治疗。对比两组临床疗效、睡眠质量、中医证候积分、生活质量。结果 治疗1个月后,研究组治疗总有效率98。00%高于对照组的86。00%(P<0。05)。治疗前,两组匹兹堡睡眠质量指数量表(PSQI)中睡眠效率、睡眠质量、入睡时间、催眠药物、睡眠时间、睡眠障碍、日间功能障碍评分对比无差异(P>0。05);治疗 1 个月后,研究组PSQI中睡眠效率、睡眠质量、入睡时间、催眠药物、睡眠时间、睡眠障碍、日间功能障碍评分分别为(1。56±0。32)、(1。37±0。54)、(1。46±0。41)、(1。02±0。34)、(1。31±0。27)、(1。22±0。43)、(1。46±0。23)分,均低于对照组的(1。93±0。45)、(1。84±0。36)、(1。83±0。37)、(1。67±0。53)、(1。86±0。42)、(1。73±0。58)、(1。93±0。37)分(P<0。05)。治疗前,两组失眠噩梦、头目昏沉、易惊易醒、烦闷急躁、胸胁胀痛积分对比无差异(P>0。05);治疗 1 个月后,研究组失眠噩梦、头目昏沉、易惊易醒、烦闷急躁、胸胁胀痛积分分别为(0。82±0。23)、(0。73±0。38)、(0。93±0。39)、(0。77±0。19)、(0。52±0。53)分,均低于对照组的(1。82±0。51)、(1。79±0。14)、(1。95±0。47)、(1。63±0。26)、(1。86±0。42)分(P<0。05)。治疗前,两组世界卫生组织生存质量测定量表(WHOQOL-100)中生理、心理、社会关系、精神/宗教信仰、环境、独立性评分对比无差异(P>0。05);治疗 1 个月后,研究组中生理、心理、社会关系、精神/宗教信仰、环境、独立性评分分别为(96。71±3。69)、(94。47±3。58)、(92。38±3。47)、(95。29±3。71)、(95。49±3。28)、(96。28±3。55)分,均高于对照组的(93。82±3。81)、(91。83±4。72)、(89。62±3。57)、(91。37±3。67)、(92。83±4。67)、(93。82±3。67)分(P<0。05)。结论 丹栀逍遥散加六味地黄丸加减治疗失眠疗效显著,可提高治疗总有效率,降低中医证候积分,从而提高睡眠质量及生活质量。
Observation on the curative effect of modified Danzhi Xiaoyao powder in the treatment of insomnia
Objective To analyze the effect of modified Danzhi Xiaoyao powder in the treatment of insomnia.Methods 100 insomnia patients were included,and divided into control group(n=50)and study group(n=50)by closed envelope method.The control group was treated with Liuwei Dihuang pill,and the study group was treated with modified Danzhi Xiaoyao powder on the basis of the control group.The clinical efficacy,sleep quality,traditional Chinese medicine syndrome score and quality of life were compared between the two groups.Results After 1 month of treatment,the total effective rate of 98.00%in the study group was higher than 86.00%in the control group(P<0.05).Before treatment,there were no differences in comparison of scores of Pittsburgh sleep quality index(PSQI)for sleep efficiency,sleep quality,sleep latency,hypnotic drugs,sleep time,sleep disturbance and daytime dysfunction between the two groups(P>0.05).After 1 month of treatment,the PSQI scores for sleep efficiency,sleep quality,sleep latency,hypnotic drugs,sleep time,sleep disturbance and daytime dysfunction of the study group were(1.56±0.32),(1.37±0.54),(1.46±0.41),(1.02±0.34),(1.31±0.27),(1.22±0.43)and(1.46±0.23)points,which were lower than(1.93±0.45),(1.84±0.36),(1.83±0.37),(1.67±0.53),(1.86±0.42),(1.73±0.58)and(1.93±0.37)points of the control group(P<0.05).Before treatment,there was no difference in the comparison of scores of insomnia and nightmares,drowsiness,easy to wake up,irritability,and chest and rib distension pain between the two groups(P>0.05).After 1 month of treatment,the scores of insomnia and nightmares,drowsiness,easy to wake up,irritability,and chest and rib distension pain in the study group were(0.82±0.23),(0.73±0.38),(0.93±0.39),(0.77±0.19),and(0.52±0.53)points,which were lower than(1.82±0.51),(1.79±0.14),(1.95±0.47),(1.63±0.26),and(1.86±0.42)points in the control group(P<0.05).Before treatment,there was no difference in the comparison of scores of World Health Organization Quality of Life Assessment(100-item version)(WHOQOL-100)for physiology,psychology,social relationships,spiritual/religious beliefs,environment and independence between the two groups(P>0.05).After 1 month of treatment,the scores of WHOQOL-100 for physiology,psychology,social relationships,spiritual/religious beliefs,environment and independence in the study group were(96.71±3.69),(94.47±3.58),(92.38±3.47),(95.29±3.71),(95.49±3.28)and(96.28±3.55)points,which were higher than(93.82±3.81),(91.83±4.72),(89.62±3.57),(91.37±3.67),(92.83±4.67)and(93.82±3.67)points in the control group(P<0.05).Conclusion The therapeutic effect of Danzhi Xiaoyao powder combined with Liuwei Dihuang pill in the treatment of insomnia is remarkable,which can improve the treatment efficiency,reduce the traditional Chinese medicine syndrome score,thus improving the sleep quality and the quality of life of patients.

Danzhi Xiaoyao powderLiuwei Dihuang pillTraditional Chinese medicine syndrome scoreSleep qualityCalm down

卢秀娥

展开 >

350000 福建省福州市仓山区城门镇卫生院中医科

丹栀逍遥散 六味地黄丸 中医证候积分 睡眠质量 镇惊安神

2024

中国现代药物应用
中国水利电力医学科学技术学会

中国现代药物应用

影响因子:0.862
ISSN:1673-9523
年,卷(期):2024.18(24)