Clinical study of monitoring renin and aldosterone and preventive intervention for gestational hypertension
Objective To analyze the application effect of renin and aldosterone level monitoring and preventive interventions in pregnant women with gestational hypertension.Methods 135 pregnant women were sampled,of which 45 healthy pregnant women served as the healthy group;the remaining 90 pregnant women with gestational hypertension were divided into a control group and an observation group according to the randomized envelope method,each with 45 cases.Pregnant women in the control group were not monitored for renin and aldosterone levels and were directly intervened with medication,while pregnant women in the observation group were monitored for renin and aldosterone levels and preventive interventions were taken.The renin and aldosterone levels of pregnant women were detected and compared bewteen the healthy group and the observation group;the blood pressure levels and the occurrence of adverse pregnancy outcome were compaared between the control group and the observation group.Results The levels of renin and aldosterone in the observation group at the time of enrollment and at 20,28 and 36 weeks of gestation were(0.26±0.19),(0.25±0.16),(0.24±0.18),(0.23±0.16)ng/(ml·h)and(12.81±3.39),(12.79±3.46),(12.72±3.37),(12.70±2.97)ng/dl,which were lower than(0.36±0.21),(0.37±0.18),(0.36±0.20),(0.36±0.19)ng/(ml·h),and(15.43±3.57),(15.50±3.58),(15.51±3.54),(15.43±3.85)ng/dl in the healthy group(P<0.05).At 28 and 36 weeks of pregnancy,the systolic and diastolic blood pressure in both groups were lower than those at the time of enrollment(P<0.05).At 28 and 36 weeks of gestation,the systolic and diastolic blood pressure in the observation group were(134.75±4.49),(127.26±5.45)and(83.34±4.17),(82.86±4.23)mm Hg(1 mm Hg=0.133 kPa),which were lower than(146.52±4.64),(145.75±4.71)and(92.39±3.51),(92.77±3.46)mm Hg in the control group(P<0.05).The rates of preterm labor of 0 and cesarean section of 40.00%in the observation group were lower than 13.33%and 82.22%in the control group(P<0.05).The incidence of fetal distress,abnormal amniotic fluid and postpartum hemorrhage in the observation group was slightly lower than those in the control group,but the difference was not significant(P>0.05).Conclusion Renin and aldosterone levels in pregnant women with gestational hypertension are lower than those in healthy pregnant women.Monitoring renin and aldosterone levels in pregnant women with gestational hypertension,establishing an early warning mechanism,and carrying out preventive interventions can enhance the effectiveness of blood pressure control and help to improve the pregnancy outcome.
万方数据
维普
