Effect analysis of salbutamol combined with ambroxol aerosol inhalation on lung function of patients with bronchiectasis
Objective To explore the effect of salbutamol combined with ambroxol aerosol inhalation on lung function of patients with bronchiectasis.Methods 74 patients operated for bronchiectasis were divided into a control group and an observation group according to the order of admission,with 37 patients in each group.The control group was treated with ambroxol aerosol inhalation,while the observation group was treated with salbutamol combined with ambroxol aerosol inhalation.The lung function indicators,cough symptoms,blood gas indicators of the two groups were compared before and after treatment.Results After treatment,the lung function indicators were improved in both groups;the observation group had peak expiratory flow rate(PEF)of(4.64±0.51)L/s,forced vital capacity(FVC)of(2.65±0.43)L,forced expiratory volume in one second(FEV1)of(2.36±0.35)L,and FEV1/FVC of(78.86±9.07)%,which were all higher than(4.13±0.47)L/s,(2.23±0.42)L,(1.82±0.34)L,and(66.58±8.63)%in the control group;the difference was statistically significant(P<0.05).After treatment,Leicester Cough Questionnaire in Mandarin-Chinese(LCQ-MC)score in both groups decreased,and LCQ-MC score of(32.07±5.44)points in the observation group was lower than(44.34±5.06)points in the control group.The difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2)increased and arterial partial pressure of carbon dioxide(PaCO2)decreased significantly in both groups;the observation group had significantly higher PaO2 of(82.85±9.73)mm Hg(1 mm Hg=0.133 kPa)than(72.62±8.67)mm Hg in the control group,and significantly lower PaCO2 of(52.07±5.33)mm Hg than(60.39±5.73)mm Hg in the control group;the difference was statistically significant(P<0.05).Conclusion Salbutamol combined with ambroxol aerosol inhalation can improve lung function,alleviate cough symptoms,and improve blood gas indicators of patients with bronchiectasis,which has promotional significance.
SalbutamolAmbroxolAerosol inhalationBronchiectasisLung functionBlood gas indicators
万方数据
维普
