Clinical efficacy and safety analysis of ropinirole in the treatment of Parkinson's disease
Objective To evaluate the effect and safety analysis of ropinirole in the treatment of Parkinson's disease.Methods 80 patients with Parkinson's disease were selected and divided into a study group and a control group by coin-tossing method,with 40 patients in each group.The control group was treated with pramipexole,and the study group was treated with ropinirole.The treatment effect,incidence of adverse reactions,symptom score and quality of life score before and after treatment were compared between the two groups.Results The total effective rate of 95.00%in the study group was higher than 77.50%in the control group(P<0.05).After treatment,the symptom scores in both groups were decreased compared with those before treatment;the scores of mental behavior emotion,motor function and daily activities in the study group were(4.51±0.62),(17.51±2.59)and(8.46±0.78)points,which were lower than(6.60±0.71),(20.10±2.61)and(10.92±1.03)points in the control group(P<0.05).After treatment,the quality of life scores in both groups were decreased compared with those before treatment;the scores of sleep,physical activity and emotional response in the study group were(10.16±1.33),(6.82±0.16)and(18.82±2.26)points,which were lower than(13.46±1.78),(10.55±0.39)and(21.55±2.09)points in the control group(P<0.05).The incidence of adverse reactions of 7.50%in the study group was lower than 25.00%in the control group(P<0.05).Conclusion The application of ropinirole in the treatment of patients with Parkinson's disease can promote the improvement of the disease,improve the quality of life,and has high safety,which has the significance of promotion and application.
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