Efficacy observation of conventional medication combined with compound Huangbai solution in the treatment of acute stage of herpes zoster
Objective To explore the efficacy of conventional medication combined with compound Huangbai solution in the treatment of acute stage of herpes zoster.Methods Clinical data of 80 patients with acute stage of herpes zoster were retrospectively analyzed and divided into combined medication group and conventional medication group,each with 40 cases.The patients in the conventional medication group were treated with conventional medication,and the patients in the combined medication group were treated with compound Huangbai solution based on the conventional medication group.Comparison was made on skin lesion score,present pain intensity(PPI)score,visual analogue scale(VAS)score,pain rating index(PRI)score,sleep interference scale(SIS)score,clinical efficacy,occurrence of adverse reactions and symptom improvement time between the two groups.Results After medication,the erythema area score,vesicle cluster number score,vesicle number score,vesicle change score,total lesion score,PPI score,VAS score,PRI score and SIS score in both groups were lower than those before medication;in the combined medication group,the erythema area score was(0.35±0.08)points,the vesicle cluster number score was(0.42±0.10)points,the vesicle number score was(0.51±0.12)points,the vesicle change score was(0.40±0.15)points,the total lesion score was(1.68±0.21)points,PPI score was(0.86±0.15)points,VAS score was(4.04±1.37)points,PRI score was(3.65±1.21)points and SIS score was(2.64±0.46)points,which were all lower than(1.05±0.12),(1.12±0.13),(1.24±0.23),(1.21±0.11),(4.62±1.02),(2.05±0.33),(4.66±0.95),(5.14±1.23)and(3.90±1.14)points in the conventional medication group;the difference was significant(P<0.05).The total effective rate of the combined medication group was 95.00%(38/40),which was higher than 75.00%(30/40)of the conventional medication group,and the difference was significant(χ2=6.275,P<0.05).The incidence of adverse drug reactions in the combined medication group was 10.00%(4/40),which was lower than 32.50%(13/40)in the conventional medication group,and the difference was significant(χ2=6.050,P<0.05).In the combined medication group,the blister stopping time was(6.26±0.97)d,the scab formation time was(8.02±0.85)d,the scab removal time was(5.02±1.03)d,the analgesia time was(6.72±1.04)d,and the healing time was(10.62±1.28)d,which were shorter than(8.00±0.76),(11.76±1.17),(8.02±1.03),(8.35±1.12),and(13.30±2.61)d in the conventional medication group,and the difference was significant(P<0.05).Conclusion The treatment effect of conventional medicine combined with compound Huangbai solution in the treatment of acute stage of herpes zoster is more significant than that of conventional medicine.
Acute stage of herpes zosterCompound Huangbai solutionSkin lesion scoreAdverse drug reactionsSymptom improvement time
万方数据
维普
